Cannabidiol attenuates the appetitive effects of Delta 9-tetrahydrocannabinol in humans smoking their chosen cannabis.
Cannabidiol attenuates the appetitive effects of Delta 9-tetrahydrocannabinol in humans smoking their chosen cannabis.
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DOI：
10.1038/npp.2010.58
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发表时间：
2010-08
影响因子：
7.6
通讯作者：
Curran, H. Valerie
中科院分区：
文献类型：
--
作者：
Morgan, Celia J. A.;Freeman, Tom P.;Schafer, Grainne L.;Curran, H. Valerie
全世界对大麻的依赖正在增加，街头大麻中 Δ9-四氢大麻酚 (THC) 的浓度也在增加。与此同时，街头大麻中第二丰富的大麻素——大麻二酚（CBD）的浓度正在下降。在实验室中施用时，这两种大麻素在药理和行为上都具有相反的作用。尚未有研究探讨这些成分的比例如何影响大麻对人类的食欲/增强作用。 94 名大麻使用者相隔 7 天接受了测试，一次在未中毒时进行，一次在严重受到自己选择的吸食大麻影响时进行依赖相关措施。使用前所未有的方法，从每个使用者身上收集大麻（以及唾液）样本，并分析大麻素的含量。根据大麻中的 CBD: THC 比率，直接比较顶部和底部三分位个体的药物增强作用、对药物刺激的外显喜好和内隐注意偏差的指数。醉酒时，与低 CBD: THC 菌株的吸烟者相比，高 CBD: THC 菌株的吸烟者对药物和食物刺激的注意力偏向减少。那些吸食较高 CBD: THC 菌株的人在两个测试日也表现出对大麻刺激的自评喜好较低。我们的研究结果表明 CBD 有潜力治疗大麻依赖。 CBD 对药物线索刺激显着性的急性调节可能会推广到其他成瘾性疾病的治疗。
Worldwide cannabis dependence is increasing, as is the concentration of the Δ9-tetrahydrocannabinol (THC) in street cannabis. At the same time, the concentration of the second most abundant cannabinoid in street cannabis, cannabidiol (CBD), is decreasing. These two cannabinoids have opposing effects both pharmacologically and behaviourally when administered in the laboratory. No research has yet examined how the ratio of these constituents impacts upon the appetitive/reinforcing effects of cannabis in humans. 94 cannabis users were tested 7 days apart, once while non-intoxicated and once while acutely under the influence of their own chosen smoked cannabis on dependence-related measures. Using an unprecedented methodology, a sample of cannabis (as well as saliva) was collected from each user and analysed for levels of cannabinoids. On the basis of CBD:THC ratios in the cannabis, individuals the top and bottom tertiles were directly compared on indices of the reinforcing effects of drugs, explicit liking and implicit attentional bias to drug stimuli. When intoxicated, smokers of high CBD:THC strains showed reduced attentional bias to drug and food stimuli compared with smokers of low CBD:THC. Those smoking higher CBD:THC strains also showed lower self-rated liking of cannabis stimuli on both test days. Our findings suggest that CBD has potential as a treatment for cannabis dependence. The acute modulation of the incentive salience of drug cues by CBD may possibly generalise to a treatment for other addictive disorders.
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影响因子：
3.4
作者：
Duka, T;Townshend, JM
通讯作者：
Townshend, JM
影响因子：
3.4
作者：
Curran, HV;Brignell, C;Henry, J
通讯作者：
Henry, J
DOI：
10.1080/09540260902782752
发表时间：
2009-04
期刊：
International review of psychiatry (Abingdon, England)
影响因子：
--
作者：
Cooper ZD;Haney M
通讯作者：
Haney M
影响因子：
5.6
作者：
Bitencourt, Rafael M.;Pamplona, Fabricio A.;Takahashi, Reinaldo N.
通讯作者：
Takahashi, Reinaldo N.
影响因子：
4.2
作者：
Field, Matt;Eastwood, Brian;Mogg, Karin
通讯作者：
Mogg, Karin