Relapsed Primary Central Nervous System Lymphoma: Current Advances.
Relapsed Primary Central Nervous System Lymphoma: Current Advances.
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DOI：
10.3389/fonc.2021.649789
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发表时间：
2021
影响因子：
4.7
通讯作者：
Tian X
中科院分区：
文献类型：
--
作者：
Tao K;Wang X;Tian X
原发性中枢神经系统淋巴瘤是一种局限于中枢神经系统的侵袭性恶性淋巴瘤。虽然接受一线治疗的患者可以达到完全缓解，但大多数患者仍会在两年内复发。复发性淋巴瘤起源于隐匿性淋巴瘤细胞，B细胞受体途径激活和免疫逃逸是PCNSL发病的关键机制。大多数复发发生在中枢神经系统，少数复发是孤立的全身性复发，临床症状出现较早且各不相同。目前复发的治疗方法包括大剂量甲氨蝶呤再激发和其他化疗方案、全脑放射治疗、造血干细胞移植、靶向治疗和免疫治疗，这些治疗方法已成为有前途的治疗方法。复发PCNSL的总体预后很差，尽管它受到许多因素的影响。本文就复发性原发性中枢神经系统淋巴瘤的发病机制、相关因素、临床特点、随访、治疗及预后进行综述。
Primary central nervous system lymphoma is an invasive malignant lymphoma confined to the central nervous system. Although patients undergoing first-line treatment can achieve complete response, most of them still relapse within two years. Relapsed lymphoma is derived from occult lymphoma cells, and B cell receptor pathway activation and immune escape are the key mechanisms for the pathogenesis of PCNSL. Most relapses are in the central nervous system, a small number of relapses are isolated systemic relapses, and clinical symptoms occur early and vary. Current treatments for relapse include high-dose methotrexate rechallenge and other regimens of chemotherapy, whole-brain radiation therapy, hematopoietic stem-cell transplantation, targeted therapy and immunotherapy, which have become promising treatments. The overall prognosis of relapsed PCNSL is very poor, although it is affected by many factors. This article summarizes the mechanisms, related factors, clinical features, follow-up, treatment and prognosis of relapsed primary central nervous system lymphoma.
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DOI：
10.1097/pai.0b013e31817bb046
发表时间：
2009-01-01
影响因子：
1.6
作者：
Chuang, Shih-Sung;Liu, Hongxiang;Lin, Li-Ching
通讯作者：
Lin, Li-Ching
影响因子：
3.9
作者：
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通讯作者：
Nishikawa, Ryo
影响因子：
3.9
作者：
Chamberlain, Marc C.
通讯作者：
Chamberlain, Marc C.
影响因子：
9.9
作者：
Enting, RH;Demopoulos, A;Abrey, LE
通讯作者：
Abrey, LE
影响因子：
0.7
作者：
Ahmed, Zartaj;Ramanathan, Ramesh K.;Halepota, Maqbool
通讯作者：
Halepota, Maqbool