The effects of age at the onset of drinking to intoxication and chronic ethanol self-administration in male rhesus macaques.
The effects of age at the onset of drinking to intoxication and chronic ethanol self-administration in male rhesus macaques.
复制标题
饮酒开始时的年龄在男性恒河猕猴中醉酒和慢性乙醇自我给药的影响。
DOI：
10.1007/s00213-013-3417-x
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发表时间：
2014-04
影响因子：
3.4
通讯作者：
Grant, Kathleen A.
中科院分区：
文献类型：
--
作者：
Helms, Christa M.;Rau, Andrew;Shaw, Jessica;Stull, Cara;Gonzales, Steven W.;Grant, Kathleen A.
关键词：
大多数人在青春期后期开始饮酒，18-25岁时饮酒最多，然后随着年龄的增长而减少。本研究在非人类灵长类动物中测量了酒精摄入量与酒精接触开始时年龄的差异，以控制人类的自我选择，并分离年龄对大量饮酒的影响。雄性恒河猴在青春期晚期（n = 8）、成年早期（n = 8）或中年早期（n = 11）被分配首次接触乙醇。在300秒的固定时间（FT）食物递送计划下，诱导猴子以增加剂量（水，0.5 g/kg, 1.0 g/kg, 1.5 g/kg）饮用乙醇（4% w/v的水），然后每天22小时同时获得乙醇和水，持续12个月。与年龄相匹配的对照组消耗了等热量麦芽糖-糊精溶液，与青少年晚期相结合，预计将迅速成熟（n = 4）。年轻成年猴子的每日乙醇摄入量和血乙醇浓度（BEC）最高。与前6个月相比，只有晚期青少年在第二个月内增加了他们的摄入量（乙醇，而不是水）。平均而言，睾酮与成熟的年龄差异一致，在整个实验过程中，睾酮的增加倾向于控制比酒精饮用的青春期猴子。在非人灵长类动物中，年轻的成年期强烈倾向于大量饮酒，这与人类存在的社会文化因素无关。在青春期晚期的关键时期饮用乙醇中毒与酗酒升级有关。
Consumption of alcohol begins during late adolescence in a majority of humans, and the greatest drinking occurs at 18–25 years then decreases with age. The present study measured differences in ethanol intake in relation to age at the onset of ethanol access among non-human primates to control for self-selection in humans and isolate age effects on heavy drinking. Male rhesus macaques were assigned first access to ethanol during late adolescence (n = 8), young adulthood (n = 8) or early middle age (n = 11). The monkeys were induced to drink ethanol (4% w/v in water) in increasing doses (water, 0.5 g/kg, 1.0 g/kg, 1.5 g/kg) using a fixed-time (FT) 300-s schedule of food delivery, followed by 22 hours/day concurrent access to ethanol and water for 12 months. Age-matched controls consumed isocaloric maltose-dextrin solution yoked to the late adolescents, expected to be rapidly maturing (n = 4). Young adult monkeys had the greatest daily ethanol intake and blood-ethanol concentration (BEC). Only late adolescents escalated their intake (ethanol, not water) during the second compared to the first 6 months of access. On average, testosterone was consistent with age differences in maturation, and tended to increase throughout the experiment more for control than ethanol-drinking adolescent monkeys. Young adulthood in non-human primates strongly disposes toward heavy drinking independently of sociocultural factors present in humans. Drinking ethanol to intoxication during the critical period of late adolescence is associated with escalation to heavy drinking.
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影响因子：
12.7
作者：
CHEN, K;KANDEL, DB
通讯作者：
KANDEL, DB
DOI：
10.1196/annals.1308.027
发表时间：
2004-01-01
期刊：
ADOLESCENT BRAIN DEVELOPMENT: VULNERABILITIES AND OPPORTUNITIES
影响因子：
--
作者：
Barr, CS;Schwandt, ML;Higley, JD
通讯作者：
Higley, JD
DOI：
10.1111/j.1530-0277.2008.00806.x
发表时间：
2008-12
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Dawson DA;Goldstein RB;Chou SP;Ruan WJ;Grant BF
通讯作者：
Grant BF
朝着全球酒精，烟草，大麻和可卡因的使用：WHO世界心理健康调查的发现。
影响因子：
15.8
作者：
Degenhardt, Louisa;Chiu, Wai-Tat;Sampson, Nancy;Kessler, Ronald C.;Anthony, James C.;Angermeyer, Matthias;Bruffaerts, Ronny;de Girolamo, Giovanni;Gureje, Oye;Huang, Yueqin;Karam, Aimee;Kostyuchenko, Stanislav;Lepine, Jean Pierre;Mora, Maria Elena Medina;Neumark, Yehuda;Ormel, J. Hans;Pinto-Meza, Alejandra;Posada-Villa, Jose;Stein, Dan J.;Takeshima, Tadashi;Wells, J. Elisabeth
通讯作者：
Wells, J. Elisabeth
影响因子：
3.4
作者：
Helms, Christa M.;McClintick, Megan N.;Grant, Kathleen A.
通讯作者：
Grant, Kathleen A.