Age at first drink and the first incidence of adult-onset DSM-IV alcohol use disorders.
Age at first drink and the first incidence of adult-onset DSM-IV alcohol use disorders.
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DOI：
10.1111/j.1530-0277.2008.00806.x
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发表时间：
2008-12
期刊：
影响因子：
--
通讯作者：
Grant BF
中科院分区：
文献类型：
--
作者：
Dawson DA;Goldstein RB;Chou SP;Ruan WJ;Grant BF
现有的研究之间的关联的年龄在第一次饮酒（AFD）和酒精使用障碍（AUD）的风险遭受不一致的控制水平和设计，可能会膨胀协会未能控制暴露于风险的持续时间。本研究探讨了AFD与（年龄<15岁和15-17岁与18岁以上）和DSM-IV酒精依赖、滥用和特定AUD标准的首次发生率，在基线时18岁及以上的美国饮酒者的纵向研究中进行3年随访（n= 22，316），控制暴露持续时间，家族史和广泛的基线和儿童期风险因素。调整所有危险因素后，AFD <15岁（OR=1.38）和15-17岁仅患有AFD的女性（OR=1.54）的依赖发生率增加。AFD <15岁和15-17岁的滥用发生率增加（OR分别为1.52和1.30）。大多数依赖标准显示出与AFD的显着关联，但危险饮酒和继续饮酒，尽管人际关系的问题是唯一的滥用标准这样做。在控制了消费量后，所有相关性都不显著，除了所有年龄<18岁的AFD与控制受损的可能性降低相关，而15-17岁的AFD与大量饮酒者中饮酒超过预期时间的可能性降低相关。在排除了具有阳性家庭史、人格障碍和儿童危险因素的低风险饮酒者人群中，早期酒精依赖（<18）与依赖发生率（OR=3.79）以及尽管身体/心理问题仍继续饮酒之间存在密切联系（OR=2.71），但与虐待发生率无关。AFD与AUD风险之间存在强有力的关联，这似乎反映了故意而不是不受控制的大量饮酒，这与执行认知功能（ECF）受损相关的决策和/或奖励处理技能差所导致的滥用一致。需要进一步的研究来确定ECF受损的因果关系，包括对低风险青少年样本的纵向研究。
Existing studies of the association between age at first drink (AFD) and the risk of alcohol use disorders (AUD) suffer from inconsistent levels of control and designs that may inflate associations by failure to control for duration of exposure to risk. This study examined associations between AFD (ages <15 and 15-17 versus 18+ years) and first incidence of DSM-IV alcohol dependence, abuse, and specific AUD criteria over a 3-year follow-up in a longitudinal study of U.S. drinkers 18 years of age and older at baseline (n=22,316), controlling for duration of exposure, family history and a wide range of baseline and childhood risk factors. After adjusting for all risk factors, the incidence of dependence was increased for AFD <15 years (OR=1.38) and for women only with AFD at ages 15-17 (OR=1.54). The incidence of abuse was increased at AFD <15 and 15-17 years (OR=1.52 and 1.30, respectively). Most dependence criteria showed significant associations with AFD, but hazardous drinking and continued drinking despite interpersonal problems were the only abuse criteria to do so. All associations were nonsignificant after controlling for volume of consumption, except that AFD at all ages <18 combined was associated with a reduced likelihood of impaired control and AFD at ages 15-17 was associated with lower odds of drinking more/longer than intended among heavy-volume drinkers. In a population of low-risk drinkers that excluded those with positive family histories, personality disorders and childhood risk factors, there were strong associations between early AFD (<18) and the incidence of dependence (OR=3.79) and continued drinking despite physical/psychological problems (OR=2.71), but no association with incidence of abuse. There is a robust association between AFD and the risk of AUD that appears to reflect willful rather than uncontrolled heavy drinking, consistent with misuse governed by poor decision-making and/or reward-processing skills associated with impaired executive cognitive function (ECF). Additional research is needed to determine causality in the role of impaired ECF, including longitudinal studies with samples of low-risk adolescents.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
DOI：
10.1111/j.1530-0277.2007.00378.x
发表时间：
2007-06-01
影响因子：
3.2
作者：
Goudriaan, Anna E.;Grekin, Emily R.;Sher, Kenneth J.
通讯作者：
Sher, Kenneth J.
DOI：
10.1007/0-306-47148-5_10
发表时间：
1998-01-01
期刊：
RECENT DEVELOPMENTS IN ALCOHOLISM, VOL 14
影响因子：
--
作者：
Giancola, PR;Moss, HB
通讯作者：
Moss, HB
影响因子：
2.6
作者：
Johnson, C. Anderson;Xiao, Lin;Bechara, Antoine
通讯作者：
Bechara, Antoine
DOI：
10.15288/jsa.1999.60.790
发表时间：
1999-11-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Canino, G;Bravo, M;Hasin, D
通讯作者：
Hasin, D