Social rank, chronic ethanol self-administration, and diurnal pituitary-adrenal activity in cynomolgus monkeys.
Social rank, chronic ethanol self-administration, and diurnal pituitary-adrenal activity in cynomolgus monkeys.
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DOI：
10.1007/s00213-012-2707-z
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发表时间：
2012-11
影响因子：
3.4
通讯作者：
Grant, Kathleen A.
中科院分区：
文献类型：
--
作者：
Helms, Christa M.;McClintick, Megan N.;Grant, Kathleen A.
优势等级影响乙醇的自我管理，与优势动物相比，从属动物的摄入量更大。过量的乙醇摄入会扰乱昼夜节律。下丘脑-垂体-肾上腺轴的昼夜节律尚未在乙醇自我给药的背景下与社会等级有关。本研究旨在确定每日垂体-肾上腺激素节律是否能解释不同社会阶层对乙醇自我使用的差异，或者是否受不同社会阶层对乙醇自我使用的差异影响。在雄性食蟹猴（Macaca fascicularis）的个体（n= 11-12）和群体（n=3组）交替居住期间，每周三次从血浆样本中获取皮质醇和促肾上腺皮质激素（ACTH）的每日测量值。确定社会等级，诱导乙醇（4%,w/v）自我给药，然后让猴子选择水或乙醇22小时/天，持续49周。对于所有社会阶层，在社会住房期间血浆ACTH升高，但皮质醇稳定，尽管优势猴子更高。无论每日乙醇摄入量（1.2-4.2 g/kg/天）如何，乙醇自我给药都减弱了社会住房、皮质醇和两种激素的昼夜节律的影响。ACTH和皮质醇的峰值更有可能在早晨乙醇摄入期间观察到。在社会住房的各个阶层中，乙醇的摄入量较低，而不是汽车。在社会住房期间，只有优势猴的血液乙醇浓度显著降低。饮用乙醇对昼夜垂体节律的干扰阈值较低，但对肾上腺皮质类固醇节律的影响持续存在。在优势猴子中防止大量饮酒可能限制了乙醇中毒，可能是为了保持优势地位。
Dominance hierarchies affect ethanol self-administration, with greater intake among subordinate animals compared to dominant animals. Excessive ethanol intake disrupts circadian rhythms. Diurnal rhythms of the hypothalamic–pituitary–adrenal axis have not been characterized in the context of ethanol self-administration with regard to social rank. This study aimed to determine whether diurnal pituitary–adrenal hormonal rhythms account for differences between social ranks in ethanol self-administration or are differentially affected by ethanol self-administration between social ranks. During alternating individual (n=11–12) and social (n=3 groups) housing of male cynomolgus monkeys (Macaca fascicularis), diurnal measures of cortisol and adrenocorticotropic hormone (ACTH) were obtained from plasma samples three times per week. Social rank was determined, ethanol (4 %, w/v) self-administration was induced, and then the monkeys were allowed a choice of water or ethanol for 22 h/day for 49 weeks. For all social ranks, plasma ACTH was elevated during social housing, but cortisol was stable, although greater among dominant monkeys. Ethanol self-administration blunted the effect of social housing, cortisol, and the diurnal rhythm for both hormones, regardless of daily ethanol intake (1.2–4.2 g/kg/day). Peak ACTH and cortisol were more likely to be observed in the morning during ethanol access. Ethanol, not vehicle, intake was lower during social housing across social ranks. Only dominant monkeys showed significantly lower blood–ethanol concentration during social housing. There was a low threshold for disruption of diurnal pituitary rhythms by ethanol drinking, but sustained adrenal corticosteroid rhythms. Protection against heavy drinking among dominant monkeys may have constrained ethanol intoxication, possibly to preserve dominance rank.
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影响因子：
3.2
作者：
Czoty PW;Gould RW;Nader MA
通讯作者：
Nader MA
影响因子：
4.7
作者：
Chen, CP;Kuhn, P;Sarkar, DK
通讯作者：
Sarkar, DK
影响因子：
10.6
作者：
Blomeyer, Dorothea;Treutlein, Jens;Laucht, Manfred
通讯作者：
Laucht, Manfred
DOI：
10.1111/j.1530-0277.1996.tb01665.x
发表时间：
1996-06-01
影响因子：
3.2
作者：
Higley, JD;Suomi, SJ;Linnoila, M
通讯作者：
Linnoila, M
DOI：
10.1007/bf00421118
发表时间：
1976-01-01
期刊：
PSYCHOPHARMACOLOGIA
影响因子：
--
作者：
KAKIHANA, R;MOORE, JA
通讯作者：
MOORE, JA