Bone hydration: How we can evaluate it, what can it tell us, and is it an effective therapeutic target?
Bone hydration: How we can evaluate it, what can it tell us, and is it an effective therapeutic target?
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DOI：
10.1016/j.bonr.2021.101161
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发表时间：
2022-06
期刊：
影响因子：
2.5
通讯作者：
Wallace JM
中科院分区：
文献类型：
--
作者：
Surowiec RK;Allen MR;Wallace JM
按体积计算，水约占皮质骨的四分之一，但可以极大地影响机械性能和组织质量。人们越来越认识到水会因年龄、疾病和治疗而动态变化。与骨力学和组织特性相关的一个关键新兴领域在于区分水在其四个不同隔室中的作用，包括自由水/孔隙水、胶原蛋白/矿物质界面松散结合的水、紧密结合在胶原蛋白三螺旋内的水以及矿物质内的结构水。这篇综述总结了我们目前对四个功能区室骨水的了解，并讨论了每个区室的变化如何与机械变化相关。它概述了能够探测骨水纳米和分子尺度的成像和光谱技术的出现和改进。这些技术进步使人们对骨水在各种条件下如何变化有了新的认识，其中包括衰老、慢性肾病、糖尿病、骨质疏松症和成骨不全症。最后，它总结了以水为治疗目标以改善机械性能的工作。骨水可以极大地影响机械性能和组织质量。骨水分为游离水/孔隙水、松散结合水、紧密结合水和结构水。骨水合作用会因健康衰老、疾病和治疗而动态变化。成像和光谱学的进步使得骨水的研究成为可能。针对骨水的治疗可能有效改善机械性能。
Water constitutes roughly a quarter of the cortical bone by volume yet can greatly influence mechanical properties and tissue quality. There is a growing appreciation for how water can dynamically change due to age, disease, and treatment. A key emerging area related to bone mechanical and tissue properties lies in differentiating the role of water in its four different compartments, including free/pore water, water loosely bound at the collagen/mineral interfaces, water tightly bound within collagen triple helices, and structural water within the mineral. This review summarizes our current knowledge of bone water across the four functional compartments and discusses how alterations in each compartment relate to mechanical changes. It provides an overview on the advent of- and improvements to- imaging and spectroscopic techniques able to probe nano-and molecular scales of bone water. These technical advances have led to an emerging understanding of how bone water changes in various conditions, of which aging, chronic kidney disease, diabetes, osteoporosis, and osteogenesis imperfecta are reviewed. Finally, it summarizes work focused on therapeutically targeting water to improve mechanical properties. Bone water can greatly influence mechanical properties and tissue quality. Bone water is found as free/pore, loosely bound, tightly bound, and structural water. Bone hydration can dynamically change due to healthy aging, disease, and treatment. Imaging and spectroscopic advances have made the study of bone water possible. Therapeutically targeting bone water may be efficacious in improving mechanical properties.
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影响因子：
4.1
作者：
Biswas, Reni;Bae, Won;Diaz, Eric;Masuda, Koichi;Chung, Christine B.;Bydder, Graeme M.;Du, Jiang
通讯作者：
Du, Jiang
影响因子：
18.3
作者：
Murray, Dylan T.;DAS, NABANITA;CROSS, TIMOTHY A.
通讯作者：
CROSS, TIMOTHY A.
DOI：
10.1098/rsif.2015.0701
发表时间：
2015-10-06
期刊：
Journal of the Royal Society, Interface
影响因子：
--
作者：
Andriotis OG;Chang SW;Vanleene M;Howarth PH;Davies DE;Shefelbine SJ;Buehler MJ;Thurner PJ
通讯作者：
Thurner PJ
影响因子：
4.2
作者：
Camacho, NP;Carroll, P;Raggio, CL
通讯作者：
Raggio, CL
影响因子：
4.4
作者：
Chang, Eric Y.;Du, Jiang;Chung, Christine B.
通讯作者：
Chung, Christine B.