Sequence of mouse hepatitis virus A59 mRNA 2: indications for RNA recombination between coronaviruses and influenza C virus.
Sequence of mouse hepatitis virus A59 mRNA 2: indications for RNA recombination between coronaviruses and influenza C virus.
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DOI：
10.1016/0042-6822(88)90512-0
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发表时间：
1988-10
期刊：
影响因子：
3.7
通讯作者：
Spaan WJ
中科院分区：
文献类型：
--
作者：
Luytjes W;Bredenbeek PJ;Noten AF;Horzinek MC;Spaan WJ
测定了冠状病毒MHV-A59基因2区的核苷酸序列。预测了两个开放阅读框(ORF)：ORF1可能编码一个261个氨基酸的蛋白质；它的氨基酸序列包含指示核苷酸结合特性的元素。ORF2编码413个氨基酸的蛋白质，缺少翻译起始密码子，因此很可能是假基因。ORF2的氨基酸序列与C型流感病毒的HA1血凝素序列有30%的同源性。ORF2上游的一小段核苷酸与MHC I类核苷酸序列有83%的同源性。我们讨论了这两种相似性是重组的结果的可能性，并提出了ORF2的获得和随后的失活的模型；该模型也适用于与MHV-A59相关的冠状病毒，我们预计ORF2在其中仍然具有功能。
The nucleotide sequence of the unique region of coronavirus MHV-A59 mRNA 2 has been determined. Two open reading frames (ORF) are predicted: ORF1 potentially encodes a protein of 261 amino acids; its amino acid sequence contains elements which indicate nucleotide binding properties. ORF2 predicts a 413 amino acids protein; it lacks a translation initiation codon and is therefore probably a pseudogene. The amino acid sequence of ORF2 shares 30% homology with the HA1 hemagglutinin sequence of influenza C virus. A short stretch of nucleotides immediately upstream of ORF2 shares 83% homology with the MHC class I nucleotide sequences. We discuss the possibilitythat both similarities are the result of recombinations and present a model for the acquisition and the subsequent inactivation of ORF2; the model applies also to MHV-A59-related coronaviruses in which we expect ORF2 to be still functional.
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影响因子：
3.7
作者：
Budzilowicz CJ;Weiss SR
通讯作者：
Weiss SR
影响因子：
56.9
作者：
DOOLITTLE, RF
通讯作者：
DOOLITTLE, RF
DOI：
10.1073/pnas.83.4.907
发表时间：
1986-02-01
影响因子：
11.1
作者：
FRY, DC;KUBY, SA;MILDVAN, AS
通讯作者：
MILDVAN, AS
影响因子：
5.4
作者：
LEIBOWITZ, JL;WEISS, SR;BOND, CW
通讯作者：
BOND, CW
影响因子：
5
作者：
KING, B;POTTS, BJ;BRIAN, DA
通讯作者：
BRIAN, DA