Meta-analysis of structural MRI studies in anorexia nervosa and the role of recovery: a systematic review protocol.
Meta-analysis of structural MRI studies in anorexia nervosa and the role of recovery: a systematic review protocol.
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DOI：
10.1186/s13643-021-01799-y
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发表时间：
2021-09-13
影响因子：
3.7
通讯作者：
Breithaupt L
中科院分区：
文献类型：
--
作者：
Dreier MJ;Van De Water AL;Kahn DL;Becker KR;Eddy KT;Thomas JJ;Holsen LM;Lawson EA;Misra M;Lyall AE;Breithaupt L
神经性厌食症 (AN) 与大脑结构异常有关。研究报告称，与健康对照相比，AN 患者的脑组织较少，脑脊液 (CSF) 较多，但由于样本量、年龄和疾病状态（例如活动性 AN、体重恢复的 AN）的差异，研究结果存在差异且不一致。此外，目前尚不清楚 AN 中观察到的大脑结构异常是否是特定脑部病理或营养不良的结果，因为 AN 的纵向神经影像研究很少完成。为了克服这个问题，这项全面的荟萃分析将结合感兴趣区域 (ROI) 和基于体素的形态测量 (VBM) 方法，以了解 AN 患者和健康对照 (HC) 个体之间的区域和整体大脑结构异常有何不同。此外，我们的目标是了解疾病过程中的临床特征和生理变化（包括急性疾病与体重恢复）如何缓解这些结构异常。我们将创建一个在线研究数据库，研究 AN 中的结构性大脑异常。数据将由我们团队的两名成员使用 MEDLINE 数据库、Web of Science、PsycINFO、EMBASE 和 CINAHL 独立审核。我们将在 AN 和 HC 中使用基于种子的 d 映射进行 ROI 和 VBM 荟萃分析。我们将纳入 1997 年 1 月至 2020 年期间 AN（急性和体重恢复）和 HC 个体的结构神经影像学研究。本系统综述将评估 AN 与 HC 相比对大脑结构的影响。此外，还将探讨急性AN和体重恢复AN对大脑结构的作用。研究结果将帮助研究人员和临床医生更好地了解 AN 的病程和恢复的性质，包括体重、营养不良和大脑状态。 PROSPERO CRD42020180921 在线版本包含可在 10.1186/s13643-021-01799-y 获取的补充材料。
Anorexia nervosa (AN) is associated with structural brain abnormalities. Studies have reported less cerebral tissue and more cerebrospinal fluid (CSF) in individuals with AN relative to healthy controls, although findings are variable and inconsistent due to variations in sample size, age, and disease state (e.g., active AN, weight-recovered AN). Further, it remains unclear if structural brain abnormalities observed in AN are a consequence of specific brain pathologies or malnutrition, as very few longitudinal neuroimaging studies in AN have been completed. To overcome this issue, this comprehensive meta-analysis will combine region-of-interest (ROI) and voxel-based morphometry (VBM) approaches to understand how regional and global structural brain abnormalities differ among individuals with AN and healthy controls (HCs). Additionally, we aim to understand how clinical characteristics and physiological changes during the course of illness, including acute illness vs. weight recovery, may moderate these structural abnormalities. We will create an online database of studies that have investigated structural brain abnormalities in AN. Data will be reviewed independently by two members of our team using MEDLINE databases, Web of Science, PsycINFO, EMBASE, and CINAHL. We will conduct ROI and VBM meta-analysis using seed-based d mapping in AN and HCs. We will include all studies that include structural neuroimaging of individuals with AN (both acute and weight-recovered) and HCs between January 1997 and 2020. This systematic review will assess the effects of AN compared to HC on brain structure. Futhermore, it will explore the role of acute AN and weight-recovered AN on brain structure. Findings will help researchers and clinicians to better understand the course of illness in AN and the nature of recovery, in terms of weight, malnutrition, and the state of the brain. PROSPERO CRD42020180921 The online version contains supplementary material available at 10.1186/s13643-021-01799-y.
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影响因子：
4.4
作者：
Titova OE;Hjorth OC;Schiöth HB;Brooks SJ
通讯作者：
Brooks SJ
影响因子：
22.4
作者：
ROSENTHAL, R
通讯作者：
ROSENTHAL, R
影响因子：
5.7
作者：
Bernardoni, Fabio;King, Joseph A.;Ehrlich, Stefan
通讯作者：
Ehrlich, Stefan
影响因子：
10.5
作者：
Papadopoulos, Fotios C.;Ekbom, Anders;Ekselius, Lisa
通讯作者：
Ekselius, Lisa
DOI：
10.1024/1422-4917/a000265
发表时间：
2014-01-01
影响因子：
1.2
作者：
Seitz, Jochen;Buehren, Katharina;Konrad, Kerstin
通讯作者：
Konrad, Kerstin