Functions of the skin microbiota in health and disease.
Functions of the skin microbiota in health and disease.
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DOI：
10.1016/j.smim.2013.09.005
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发表时间：
2013-11-30
影响因子：
7.8
通讯作者：
Gallo RL
中科院分区：
文献类型：
--
作者：
Sanford JA;Gallo RL
皮肤是人体最大的器官，是多种多样和复杂的先天和适应性免疫功能的家园。尽管这种有效的免疫系统存在于皮肤屏障，但皮肤鼓励微生物的定植。表征这些微生物群落增强了我们对正常皮肤中存在的生物体生态学的了解;此外，研究已经开始揭示宿主和常驻微生物之间的亲密关系。特别是，很明显，正如宿主免疫因素和行为塑造了这些群落的组成一样，皮肤上存在的微生物极大地影响了人体免疫功能。因此，今天的皮肤免疫系统应该被认为是来自宿主和微生物的元素的集体混合物，它们以互利关系起作用。在本文中，我们将回顾皮肤微生物群落与宿主免疫相互作用的最新发现，并讨论这些群落的生态失调在皮肤疾病中所发挥的作用。
The skin, the human body’s largest organ, is home to a diverse and complex variety of innate and adaptive immune functions. Despite this potent immune system present at the cutaneous barrier, the skin encourages colonization by microorganisms. Characterization these microbial communities has enhanced our knowledge of the ecology of organisms present in normal skin; furthermore, studies have begun to bring to light the intimate relationships shared between host and resident microbes. In particular, it is apparent that just as host immunological factors and behaviors shape the composition of these communities, microbes present on the skin greatly impact the functions of human immunity. Thus, today the skin immune system should be considered a collective mixture of elements from the host and microbes acting in a mutualistic relationship. In this article we will review recent findings of the interactions of skin microbial communities with host immunity, and discuss the role that dysbiosis of these communities plays in diseases of the skin.
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影响因子：
6.4
作者：
Coelho MA;Sampaio JP;Gonçalves P
通讯作者：
Gonçalves P
影响因子：
1.4
作者：
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通讯作者：
Gallo, Richard L.
影响因子：
6.5
作者：
Capone, Kimberly A.;Dowd, Scot E.;Stamatas, Georgios N.;Nikolovski, Janeta
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Nikolovski, Janeta
影响因子：
3.7
作者：
Cogen AL;Yamasaki K;Muto J;Sanchez KM;Crotty Alexander L;Tanios J;Lai Y;Kim JE;Nizet V;Gallo RL
通讯作者：
Gallo RL
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者：
Knight, Rob