Advances and potential of omics studies for understanding the development of food allergy.
Advances and potential of omics studies for understanding the development of food allergy.
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DOI：
10.3389/falgy.2023.1149008
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发表时间：
2023
影响因子：
--
通讯作者：
Chinthrajah, R. Sharon
中科院分区：
文献类型：
--
作者：
Sindher, Sayantani B.;Chin, Andrew R.;Aghaeepour, Nima;Prince, Lawrence;Maecker, Holden;Shaw, Gary M.;Stevenson, David K.;Nadeau, Kari C.;Snyder, Michael;Khatri, Purvesh;Boyd, Scott D.;Winn, Virginia D.;Angst, Martin S.;Chinthrajah, R. Sharon
食物过敏的患病率在全球范围内持续上升，带来了巨大的安全，经济和情感负担。虽然预防策略确实存在，但过敏轨迹和临床表型的异质性使得难以识别将从这些策略中受益的患者。因此，需要进一步研究区分这些轨迹的分子机制。大规模的组学研究已经确定了许多不同疾病的分子机制的关键见解，然而，这些技术在揭示食物过敏发展驱动因素方面的应用仍处于起步阶段。在这里，我们回顾了组学方法在食物过敏中的应用，并强调了应用这些技术表征食物过敏发展的关键知识差距。
The prevalence of food allergy continues to rise globally, carrying with it substantial safety, economic, and emotional burdens. Although preventative strategies do exist, the heterogeneity of allergy trajectories and clinical phenotypes has made it difficult to identify patients who would benefit from these strategies. Therefore, further studies investigating the molecular mechanisms that differentiate these trajectories are needed. Large-scale omics studies have identified key insights into the molecular mechanisms for many different diseases, however the application of these technologies to uncover the drivers of food allergy development is in its infancy. Here we review the use of omics approaches in food allergy and highlight key gaps in knowledge for applying these technologies for the characterization of food allergy development.
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影响因子：
14.2
作者：
Crestani, Elena;Harb, Hani;Chatila, Talal A.
通讯作者：
Chatila, Talal A.
影响因子：
12.4
作者：
Elizur, Arnon;Appel, Michael Y.;Goldberg, Michael R.
通讯作者：
Goldberg, Michael R.
DOI：
10.1016/j.anai.2021.04.036
发表时间：
2021-09
期刊：
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
影响因子：
--
作者：
Gabryszewski SJ;Hill DA
通讯作者：
Hill DA
DOI：
10.1016/j.plefa.2020.102099
发表时间：
2020-08-01
影响因子：
3
作者：
Ellul, Susan;Marx, Wolfgang;Sly, Peter
通讯作者：
Sly, Peter
影响因子：
168.9
作者：
Chinthrajah, R. Sharon;Purington, Natasha;Nadeau, Kari C.
通讯作者：
Nadeau, Kari C.