Protein targeting and transport as a necessary consequence of increased cellular complexity.

Protein targeting and transport as a necessary consequence of increased cellular complexity.
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细胞复杂性增加所必需的蛋白质靶向和运输

DOI:
10.1101/cshperspect.a016055
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发表时间:
2014
影响因子:
7.2
通讯作者:
Schleiff E
Schleiff E
中科院分区:
生物学1区
文献类型:
--
作者:
Sommer MS;Schleiff E

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随着细胞内复杂性的增加,出现了一个新的细胞生物学问题,即胞质合成的蛋白质在细胞内的最终目的地的分配。因此,一个特殊的挑战是蛋白质进入或穿过细胞膜的易位。其基本机制只有部分是很好理解的,但可以假设细胞进化的过程对所需分子机器的设计产生了深刻的影响。在本文中,我们的目的是总结蛋白质运输进化发展的当前知识和概念,作为细胞复杂性增加的必要前提和后果。
With increasing intracellular complexity, a new cell-biological problem that is the allocation of cytoplasmically synthesized proteins to their final destinations within the cell emerged. A special challenge is thereby the translocation of proteins into or across cellular membranes. The underlying mechanisms are only in parts well understood, but it can be assumed that the course of cellular evolution had a deep impact on the design of the required molecular machines. In this article, we aim to summarize the current knowledge and concepts of the evolutionary development of protein trafficking as a necessary premise and consequence of increased cellular complexity.
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