Gender differences among criminal justice-involved persons living with HIV interested in extended-release naltrexone treatment.
Gender differences among criminal justice-involved persons living with HIV interested in extended-release naltrexone treatment.
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DOI：
10.1080/08897077.2021.1900984
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发表时间：
2021
期刊：
影响因子：
3.5
通讯作者：
Springer SA
中科院分区：
文献类型：
--
作者：
Biondi BE;Frank CA;Forray A;Springer SA
先前的研究表明，在物质使用障碍（sud）的药物治疗方面存在性别差异，但很少有研究调查同意接受缓释纳曲酮（XR-NTX）治疗的参与者之间的性别差异。了解性别差异对于制定干预措施以克服开始和坚持sud药物治疗的障碍至关重要。研究人员分析了XR-NTX在离开刑事司法系统（CJS）的艾滋病毒和酒精或阿片类药物使用障碍患者中进行的两项双盲安慰剂对照试验的数据，以了解临床特征、心理健康、药物使用严重程度和其他领域的性别差异。招募酒精使用障碍（AUD）患者的研究于2010年9月至2016年2月在康涅狄格州（CT）的两个地点进行，阿片类药物使用障碍（OUD）研究于2010年9月至2016年3月在CT的三个地点和马萨诸塞州的一个地点进行。基线数据分析来自193名同意随机接受XR-NTX或安慰剂治疗的参与者；40名女性和153名男性。女性更年轻，精神健康严重程度更差，更有可能被诊断为可卡因使用障碍。在抗逆转录病毒治疗（ART）处方或ART依从性方面，男性和女性之间没有统计学差异。与男性相比，女性的精神健康严重程度更高，可卡因使用的流行率也更高，众所周知，这两者都是参与和坚持对酒精和阿片类药物使用障碍进行药物治疗的障碍。对于患有CJS且同时感染HIV和sud的女性，了解可能影响sud药物治疗开始和维持的因素对于改善女性的治疗效果是必要的。
Previous research has shown gender differences with respect to entry into medication treatment of substance use disorders (SUDs), yet few have examined gender differences among participants consented to be treated with extended-release naltrexone (XR-NTX). Understanding gender differences is critical to developing interventions to overcome barriers to initiation of and retention on medication treatment for SUDs. Data from two double-blind placebo-controlled trials of XR-NTX among persons with HIV and alcohol or opioid use disorders leaving the criminal justice system (CJS) were analyzed for gender differences among clinical characteristics, mental health, drug use severity, and other domains. The study that recruited persons with alcohol use disorder (AUD) was conducted from September 2010–February 2016 at two sites in Connecticut (CT), and the opioid use disorder (OUD) study was conducted from September 2010–March 2016 at three sites in CT and one site in Massachusetts. Baseline data were analyzed from 193 participants consented to be randomized to XR-NTX or placebo; 40 women and 153 men. Women were younger, had worse mental health severity, and were more likely to be diagnosed with cocaine use disorder. There were no statistical differences between men and women in the prescription of antiretroviral therapy (ART) or ART adherence. Women had greater mental health severity and a higher prevalence of cocaine use as compared to men, both of which are known to be barriers to engagement and retention on medication treatment for alcohol and opioid use disorders. For women with CJS involvement and living with HIV and SUDs, understanding factors that may affect initiation and retention on medication treatment of SUDs are necessary to improve treatment outcomes in women.
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影响因子：
2
作者：
Mbaba M;Brown SE;Wooditch A;Kiss M;Murphy A;Kumari S;Taxman F;Altice F;Lawson WB;Springer SA
通讯作者：
Springer SA
影响因子：
3.5
作者：
Meyer, Jaimie P.;Springer, Sandra A.;Altice, Frederick L.
通讯作者：
Altice, Frederick L.
影响因子：
4.2
作者：
Hernandez-Avila, CA;Rounsaville, BJ;Kranzler, HR
通讯作者：
Kranzler, HR
影响因子：
3.9
作者：
McHugh, R. Kathryn;DeVito, Elise E.;Weiss, Roger D.
通讯作者：
Weiss, Roger D.
DOI：
10.1177/2325957414536228
发表时间：
2016-01-01
影响因子：
--
作者：
Aljassem, Kinda;Raboud, Janet M;Loutfy, Mona R
通讯作者：
Loutfy, Mona R