5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice.
5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice.
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5-FU-水凝胶抑制小鼠结直肠腹膜癌病和肿瘤生长
DOI：
10.1186/1471-2407-10-402
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发表时间：
2010-08-02
期刊：
影响因子：
3.8
通讯作者：
Wei Y
中科院分区：
文献类型：
--
作者：
Wang Y;Gong C;Yang L;Wu Q;Shi S;Shi H;Qian Z;Wei Y
背景结直肠腹膜癌病（CRPC）是腹腔内癌症全身转移的常见形式。腹腔内化疗是结直肠癌的优选选择。我们报道了一种新的系统——负载5-FU的水凝胶系统，可以提高腹腔化疗的治疗效果。方法成功合成了可生物降解的PEG-PCL-PEG（PECE）三嵌段共聚物。开发了可生物降解且温度敏感的水凝胶来负载 5-FU。还开发了载有亚甲基蓝的水凝胶用于药物释放的可见观察。在小鼠CRPC模型中评估了5-FU-水凝胶系统的效果和毒性。结果水凝胶系统在环境温度下是可注射的流动溶液，在生理温度下形成不流动的凝胶库。随后将 5-FU-水凝胶注射到 CT26 癌细胞腹膜播散的小鼠腹腔内。结果表明，水凝胶递送系统延长了亚甲基蓝的释放； 5-FU-水凝胶显着抑制CT26细胞的腹膜播散和生长。此外，腹腔内给予5-FU-水凝胶具有良好的耐受性，并且表现出较低的血液毒性。结论我们的数据表明，5-FU-水凝胶系统可以被认为是腹膜癌转移的新策略，并且水凝胶可以为癌症腹膜癌转移提供负载不同化疗药物的潜在递送系统。
BackgroundColorectal peritoneal carcinomatosis (CRPC) is a common form of systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy is a preferable option for colorectal cancer. Here we reported that a new system, 5-FU-loaded hydrogel system, can improve the therapeutic effects of intraperitoneal chemotherapy.MethodsA biodegradable PEG-PCL-PEG (PECE) triblock copolymer was successfully synthesized. The biodegradable and temperature sensitive hydrogel was developed to load 5-FU. Methylene blue-loaded hydrogel were also developed for visible observation of the drug release. The effects and toxicity of the 5-FU-hydrogel system were evaluated in a murine CRPC model.ResultsThe hydrogel system is an injectable flowing solution at ambient temperature and forms a non-flowing gel depot at physiological temperature. 5-FU-hydrogel was subsequently injected into abdominal cavity in mice with CT26 cancer cells peritoneal dissemination. The results showed that the hydrogel delivery system prolonged the release of methylene blue; the 5-FU-hydrogel significantly inhibited the peritoneal dissemination and growth of CT26 cells. Furthermore, intraperitoneal administration of the 5-FU-hydrogel was well tolerated and showed less hematologic toxicity.ConclusionsOur data indicate that the 5-FU-hydrogel system can be considered as a new strategy for peritoneal carcinomatosis, and the hydrogel may provide a potential delivery system to load different chemotherapeutic drugs for peritoneal carcinomatosis of cancers.
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影响因子：
3.7
作者：
Esquivel, J.;Sticca, R.;Sebbag, G.
通讯作者：
Sebbag, G.
影响因子：
4.1
作者：
Gong, ChangYang;Qian, ZhiYong;Wei, YuQuan
通讯作者：
Wei, YuQuan
DOI：
10.1002/jbm.b.30858
发表时间：
2008-01-01
影响因子：
3.4
作者：
Liu, Cai Bing;Gong, Chang Yang;Qian, Zhi Yong
通讯作者：
Qian, Zhi Yong
影响因子：
64.8
作者：
Miyata, T;Asami, N;Uragami, T
通讯作者：
Uragami, T
影响因子：
3.7
作者：
Elias, Dominique;Goere, Diane;Raynard, Bruno
通讯作者：
Raynard, Bruno