Experimental evaluation of the patient-specific haemodynamics of an aortic dissection model using particle image velocimetry.
Experimental evaluation of the patient-specific haemodynamics of an aortic dissection model using particle image velocimetry.
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DOI：
10.1016/j.jbiomech.2022.110963
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发表时间：
2022-03
影响因子：
2.4
通讯作者：
Balabani, Stavroula
中科院分区：
文献类型：
--
作者：
Franzetti, Gaia;Bonfanti, Mirko;Homer-Vanniasinkam, Shervanthi;Diaz-Zuccarini, Vanessa;Balabani, Stavroula
主动脉夹层（AD）是一种影响主动脉的复杂病理。诊断、管理和治疗仍然是一个挑战，因为它是一种高度患者特异性的病理学，并且对临床结果背后的流体力学现象的理解仍然有限。虽然体外模型可以允许在物理幻影AD流场的准确研究，他们目前是稀缺的，几乎完全依赖于过于简化的假设。在这项工作中，我们提出了第一个实验研究的患者特定的情况下，AD。根据临床数据，制作了解剖学上正确的体模，并与最先进的体外平台相结合，用于准确地再现个性化条件。通过流速和压力采集以及粒子图像测速（PIV）导出的速度场表征了平台再现的复杂AD血流动力学。临床相关的血液动力学指标，可以与AD的预后-如速度，剪切率，湍流动能分布-提取在两个区域的兴趣在主动脉域。所获得的数据突出了血流的复杂性（例如，再循环区域、假腔中的低剪切率），并且与现有临床数据和同时进行的研究的CFD结果非常一致，证明了结果的准确性。这些结果表明，所描述的平台构成了一个强大的，独特的工具，以重现体外个性化的血液动力学条件，可用于支持外科手术，医疗器械测试的评价和验证最先进的数值模型。
Aortic Dissection (AD) is a complex pathology that affects the aorta. Diagnosis, management and treatment remain a challenge as it is a highly patient-specific pathology and there is still a limited understanding of the fluid-mechanics phenomena underlying clinical outcomes. Although in vitro models can allow the accurate study of AD flow fields in physical phantoms, they are currently scarce and almost exclusively rely on over simplifying assumptions. In this work, we present the first experimental study of a patient-specific case of AD. An anatomically correct phantom was produced and combined with a state-of-the-art in vitro platform, informed by clinical data, employed to accurately reproduce personalised conditions. The complex AD haemodynamics reproduced by the platform was characterised by flow rate and pressure acquisitions as well as Particle Image Velocimetry (PIV) derived velocity fields. Clinically relevant haemodynamic indices, that can be correlated with AD prognosis – such as velocity, shear rate, turbulent kinetic energy distributions – were extracted in two regions of interest in the aortic domain. The acquired data highlighted the complex nature of the flow (e.g. recirculation regions, low shear rate in the false lumen) and was in very good agreement with the available clinical data and the CFD results of a study conducted alongside, demonstrating the accuracy of the findings. These results demonstrate that the described platform constitutes a powerful, unique tool to reproduce in vitro personalised haemodynamic conditions, which can be used to support the evaluation of surgical procedures, medical devices testing and to validate state-of-the-art numerical models.
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影响因子：
2.2
作者：
Bonfanti, Mirko;Franzetti, Gaia;Diaz-Zuccarini, Vanessa
通讯作者：
Diaz-Zuccarini, Vanessa
影响因子：
4.6
作者：
Girish, Apoorva;Padala, Muralidhar;Leshnower, Bradley G.
通讯作者：
Leshnower, Bradley G.
影响因子：
19.7
作者：
Chung, JW;Elkins, C;Dake, MD
通讯作者：
Dake, MD
DOI：
10.1098/rsif.2017.0632
发表时间：
2017-11
期刊：
Journal of the Royal Society, Interface
影响因子：
--
作者：
Bonfanti M;Balabani S;Greenwood JP;Puppala S;Homer-Vanniasinkam S;Díaz-Zuccarini V
通讯作者：
Díaz-Zuccarini V
DOI：
10.1115/1.4023132
发表时间：
2013-01-01
影响因子：
1.7
作者：
Kousera, C. A.;Wood, N. B.;Xu, X. Y.
通讯作者：
Xu, X. Y.