Association between subjective memory assessment and associative memory performance: Role of ad risk factors.
Association between subjective memory assessment and associative memory performance: Role of ad risk factors.
复制标题
DOI：
10.1037/pag0000217
复制
发表时间：
2018-03
影响因子：
3.7
通讯作者：
Rodrigue KM
中科院分区：
文献类型：
--
作者：
Horn MM;Kennedy KM;Rodrigue KM
联想记忆能力下降是老年人常见的认知问题，在正常衰老和前驱阿尔茨海默病 (AD) 中均可检测到。主观记忆（SM）抱怨可能是这些助记变化的早期标志；然而，先前研究主观记忆对观察到的记忆表现的预测效用产生了不一致的结果。这种不一致可能是由于记忆力下降时出现的其他差异来源造成的，例如情绪/抑郁问题、载脂蛋白 E (APOE ε4) 基因型的存在或 β-淀粉样蛋白沉积。在这里，我们在 195 名 20-94 岁健康成年人（79 名男性）中，以增加 AD 易感性的因素为背景，研究 SM 和联想记忆能力之间的关系。参与者完成了主观记忆问卷、情绪/抑郁量表、两项联想记忆测试（单词对和名字-面孔测试），并进行了 APOE ε4 基因分型。收集了 50 岁以上人群的 PET-淀粉样蛋白成像数据 (N = 74)。我们发现，即使在年龄、性别、情绪和 APOE ε4 状态共变之后，SM 仍能预测两项联想记忆测试的表现。有趣的是，对于姓名-面孔关联任务，主观记忆关注的增加选择性地预测了 60 岁以上参与者的记忆表现，其中 APOEε4 风险组表现出最强的效果。最后，β-淀粉样蛋白沉积较高的男性报告了更多的记忆问题。我们的研究结果表明，即使在认知健康的成年人中，SM 也能可靠地跟踪记忆表现，并且可能反映出患阿尔茨海默病的风险增加。
Decline in associative memory abilities is a common cognitive complaint among older adults and is detectable in both normal aging and in prodromal Alzheimer’s disease (AD). Subjective memory (SM) complaints may serve as an earlier marker of these mnemonic changes; however, previous research examining the predictive utility of subjective memory to observed memory performance yielded inconsistent results. This inconsistency is likely due to other sources of variance that occur with memory decline such as mood/depression issues, presence of Apolipoprotein E (APOE ε4) genotype, or beta-amyloid deposition. Here we examine the relationship between SM and associative memory ability in the context of factors that increase susceptibility to AD in 195 healthy adults (79 men) aged 20–94 years. Participants completed a subjective memory questionnaire, a mood/depression scale, two associative memory tests (a word-pair and a name-face test) and were genotyped for APOE ε4. PET-amyloid imaging data were collected for a subset of those over 50 years of age (N= 74). We found that SM predicted performance on both associative memory tests even after covarying for age, sex, mood, and APOE ε4 status. Interestingly, for the name-face associative task, increased subjective memory concerns predicted memory performance selectively in participants over the age of 60, with APOEε4 risk group showing the strongest effect. Finally, men with higher beta-amyloid deposition reported more memory complaints. Our findings suggest that SM reliably tracks memory performance, even in cognitively healthy adults, and may reflect an increased risk for Alzheimer’s disease.
登录
查看更多内容
影响因子：
2.6
作者：
Amariglio RE;Becker JA;Carmasin J;Wadsworth LP;Lorius N;Sullivan C;Maye JE;Gidicsin C;Pepin LC;Sperling RA;Johnson KA;Rentz DM
通讯作者：
Rentz DM
影响因子：
2.4
作者：
Herlitz, A;Airaksinen, E;Nordström, E
通讯作者：
Nordström, E
影响因子：
6.6
作者：
GOLINKOFF, M;SWEENEY, JA
通讯作者：
SWEENEY, JA
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
DOI：
10.1016/s0022-5371(72)80001-x
发表时间：
1972-01-01
期刊：
JOURNAL OF VERBAL LEARNING AND VERBAL BEHAVIOR
影响因子：
--
作者：
CRAIK, FIM;LOCKHART, RS
通讯作者：
LOCKHART, RS