Mild and moderate cognitive impairment and mortality among Brazilian older adults in long-term follow-up: The Bambui Health Aging Study.
Mild and moderate cognitive impairment and mortality among Brazilian older adults in long-term follow-up: The Bambui Health Aging Study.
复制标题
DOI：
10.1590/1516-4446-2019-0654
复制
发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Castro-Costa E
中科院分区：
文献类型：
--
作者：
Campos CG;Diniz BS;Firmo JO;Lima-Costa MF;Blay SL;Castro-Costa E
比较一个中等收入国家有和没有轻度或中度认知障碍的老年人在15年随访期间的死亡率，该国家在这方面的信息很少。共有1281名居住在社区的老年人接受了中位数为13.3年的随访。我们使用迷你精神状态检查评估他们的认知障碍，将其分为无（高于临界值1.0 SD）、轻度（低于临界值1.0 SD）或中度（低于临界值2.0 SD）。死亡日期是通过审查死亡证明确定的。Cox比例风险模型用于评估认知障碍患者的死亡风险。在未调整的模型中，轻度或中度认知障碍的参与者比没有认知障碍的参与者有更高的死亡风险，但这些关联在最终模型中没有保留。在性别分层后，在最终模型中，只有中度认知障碍的男性有更高的死亡风险。研究结果表明，在一项大型巴西老年人队列中，中度认知障碍与男性全因死亡率之间存在关联。
To compare mortality in older adults with and without mild or moderate cognitive impairment over 15 years of follow-up in a middle-income country, where little information on this subject is available. A total of 1,281 community-dwelling older adults were followed-up for a median of 13.3 years. We evaluated their cognitive impairment using the Mini-Mental State Examination, categorizing it as none (1.0 SD above cutoff means), mild (1.0 SD below cutoff means) or moderate (2.0 SD below cutoff means). The date of death was determined by reviewing death certificates. Cox’s proportional hazards models were used to evaluate the risk of mortality in participants with cognitive impairment. Participants with mild or moderate cognitive impairment had a higher mortality risk than those without it in the unadjusted model, but these associations did not remain in the final model. After sex stratification, only men with moderate cognitive impairment had a higher mortality risk in the final model. The findings suggest an association between moderate cognitive impairment and all-cause mortality in men in a large Brazilian cohort of older adults.
登录
查看更多内容
影响因子：
2.2
作者：
Ormstad, Heidi;Rosness, Tor A.;Strand, Bjorn Heine
通讯作者：
Strand, Bjorn Heine
影响因子：
--
作者：
Moritz, DJ;Fox, PJ;Kraemer, HC
通讯作者：
Kraemer, HC
影响因子：
16.4
作者：
Cumming, G;Finch, S
通讯作者：
Finch, S
影响因子：
4
作者：
Castro-Costa, Erico;Dewey, Michael E.;Stewart, Robert
通讯作者：
Stewart, Robert
DOI：
10.1016/j.jalz.2011.03.008
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Albert MS;DeKosky ST;Dickson D;Dubois B;Feldman HH;Fox NC;Gamst A;Holtzman DM;Jagust WJ;Petersen RC;Snyder PJ;Carrillo MC;Thies B;Phelps CH
通讯作者：
Phelps CH