Local Chemotherapy as an Adjuvant Treatment in Unresectable Squamous Cell Carcinoma: What Do We Know So Far?
Local Chemotherapy as an Adjuvant Treatment in Unresectable Squamous Cell Carcinoma: What Do We Know So Far?
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DOI：
10.3390/curroncol28040213
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发表时间：
2021-06-23
期刊：
影响因子：
--
通讯作者：
Nisticò SP
中科院分区：
文献类型：
--
作者：
Bennardo L;Bennardo F;Giudice A;Passante M;Dastoli S;Morrone P;Provenzano E;Patruno C;Nisticò SP
背景：鳞状细胞癌（Squamous cell carcinoma，SCC）是最常见的皮肤和口腔粘膜恶性肿瘤之一。虽然这种情况的金标准治疗是手术切除病变，但在某些情况下，由于患者不适合手术，医生必须提出替代治疗方案。在可用的替代疗法中，局部化疗可能是与放疗或全身化疗联合的初始治疗，因为副作用的频率较低，并且不需要昂贵的设备。研究方法：在本文中，我们回顾了各种数据库（PubMed，Scopus-Embase，Web of Science）中所有可用的文献，提出局部化疗作为皮肤和口腔SCC的治疗方法。排除标准包括眼部病变（局部治疗常见）、非英语语言和非人类研究。结果：我们纳入了14项研究。大多数是病例报告和病例系列，描述了咪喹莫特或5-氟尿嘧啶治疗不可切除的局部SCC。我们还分析了提出联合治疗的小型研究。几乎所有的研究都报告了良好的临床结局，随着时间的推移复发的风险很低。结论：病灶切除仍然是SCC的金标准治疗。当这种方法不可行时，局部化疗可能是一种治疗选择，也可能与放疗或全身化疗相关。
Background: Squamous cell carcinoma (SCC) is one of the most common cancers involving skin and oral mucosa. Although this condition’s gold-standard treatment is the surgical removal of the lesions, the physician must propose alternative treatments in some cases due to the patient’s ineligibility for surgery. Among the available alternative therapies, local chemotherapy may represent an initial treatment in combination with radiotherapy or systemic chemotherapy due to the low frequency of side-effects and the lack of necessity for expensive devices. Methods: In this paper, we review all available literature in various databases (PubMed, Scopus-Embase, Web of Science), proposing local chemotherapy as a treatment for cutaneous and oral SCC. Exclusion criteria included ocular lesions (where topical treatments are common), non-English language, and non-human studies. Results: We included 14 studies in this review. The majority were case reports and case series describing the treatment of non-resectable localized SCC with either imiquimod or 5-fluorouracil. We also analyzed small studies proposing combination treatments. Almost all studies reported an excellent clinical outcome, with a low risk of relapses in time. Conclusions: Resection of the lesion remains the gold-standard treatment for SCC. When this approach is not feasible, local chemotherapy may represent a treatment alternative, and it may also be associated with radiotherapy or systemic chemotherapy.
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DOI：
10.1016/j.omto.2020.10.009
发表时间：
2020-12-16
期刊：
Molecular therapy oncolytics
影响因子：
--
作者：
Inoue J;Fujiwara K;Hamamoto H;Kobayashi K;Inazawa J
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影响因子：
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作者：
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10.1111/j.1468-3083.2004.00852.x
发表时间：
2004-01-01
影响因子：
9.2
作者：
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通讯作者：
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影响因子：
3.8
作者：
Biamonte, Flavia;Buffone, Caterina;Giudice, Amerigo
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Giudice, Amerigo
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影响因子：
5.2
作者：
Garofoli M;Volpicella M;Guida M;Porcelli L;Azzariti A
通讯作者：
Azzariti A