Determinants of phthalate exposures in pregnant women in New York City.
Determinants of phthalate exposures in pregnant women in New York City.
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DOI：
10.1016/j.envres.2022.113203
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发表时间：
2022-09
影响因子：
8.3
通讯作者：
Trasande, Leonardo
中科院分区：
文献类型：
--
作者：
Liu, Hongxiu;Wang, Yuyan;Kannan, Kurunthachalam;Liu, Mengling;Zhu, Hongkai;Chen, Yu;Kahn, Linda G.;Jacobson, Melanie H.;Gu, Bo;Mehta-Lee, Shilpi;Brubaker, Sara G.;Ghassabian, Akhgar;Trasande, Leonardo
以前的研究提供了孕妇邻苯二甲酸酯决定因素的数据，但结果在不同地区是不同的。我们的目的是确定预测邻苯二甲酸酯暴露在美国城市当代妊娠队列的食物组和人口统计学因素。这项研究包括来自纽约市纽约大学儿童健康与环境研究的450名孕妇。通过液相色谱-串联质谱法，在妊娠期间的三个时间点测定了22种邻苯二甲酸酯代谢物（包括邻苯二甲酸二-2-乙基己酯（DEHP）代谢物）的尿液浓度。孕妇在妊娠中期完成饮食史问卷II，以评估饮食信息。线性混合模型拟合，以检查尿邻苯二甲酸酯代谢物浓度的决定因素。使用部分线性单指数（PLSI）模型，我们评估了主要贡献者，在10个食物组中，邻苯二甲酸酯暴露。在>90%的样本中发现了DEHP及其邻苯二甲酸酯替代物邻苯二甲酸二异壬酯（DiNP）。肌酐调整的DiNP代谢物浓度的总和较高，在老年和单身妇女和在夏季收集的样本。与非西班牙裔白色女性相比，西班牙裔和非西班牙裔黑人女性的邻苯二甲酸二正辛酯（DnOP）总代谢物尿液浓度较低，但低分子量邻苯二甲酸酯浓度较高。谷物产品的消费量每增加一倍，可使DiNP浓度增加20.9%（95%CI：4.5，39.9）。PLSI模型显示，干豆和豌豆的摄入量是影响尿液中DEHP、DiNP和DnOP水平的主要膳食因素，贡献比例分别为76.3%、35.8%和27.4%。纽约市孕妇尿中邻苯二甲酸酯代谢物水平因年龄、婚姻状况、季节性、种族/民族和饮食而异。这些结果有助于了解邻苯二甲酸酯水平的主要决定因素，并可用于识别暴露源和指导干预措施，以减少易感人群的暴露。
Previous studies have provided data on determinants of phthalates in pregnant women, but results were disparate across regions. We aimed to identify the food groups and demographic factors that predict phthalate exposure in an urban contemporary pregnancy cohort in the US. The study included 450 pregnant women from the New York University Children’s Health and Environment Study in New York City. Urinary concentrations of 22 phthalate metabolites, including metabolites of di-2-ethylhexylphthalate (DEHP), were determined at three time points across pregnancy by liquid chromatography coupled with tandem mass spectrometry. The Diet History Questionnaire II was completed by pregnant women at mid-pregnancy to assess dietary information. Linear mixed models were fitted to examine determinants of urinary phthalate metabolite concentrations. Using partial-linear single-index (PLSI) models, we assessed the major contributors, among ten food groups, to phthalate exposure. Metabolites of DEHP and its ortho-phthalate replacement, diisononyl phthalate (DiNP), were found in >90% of the samples. The sum of creatinine-adjusted DiNP metabolite concentrations was higher in older and single women and in samples collected in summer. Hispanic and non-Hispanic Black women had lower urinary concentrations of summed metabolites of di-n-octyl phthalate (DnOP), but higher concentrations of low molecular weight phthalates compared with non-Hispanic White women. Each doubling of grain products consumed was associated with a 20.9% increase in ΣDiNP concentrations (95%CI: 4.5, 39.9). PLSI models revealed that intake of dried beans and peas was the main dietary factor contributing to urinary ΣDEHP, ΣDiNP, and ΣDnOP levels, with contribution proportions of 76.3%, 35.8%, and 27.4%, respectively. Urinary metabolite levels of phthalates in pregnant women in NYC varied by age, marital status, seasonality, race/ethnicity, and diet. These results lend insight into the major determinants of phthalates levels, and may be used to identify exposure sources and guide interventions to reduce exposures in susceptible populations.
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DOI：
10.1038/nrendo.2016.186
发表时间：
2017-03
期刊：
Nature reviews. Endocrinology
影响因子：
--
作者：
Braun JM
通讯作者：
Braun JM
影响因子：
11.8
作者：
Cantonwine, David E.;Cordero, Jose F.;Rivera-Gonzalez, Luis O.;Del Toro, Liza V. Anzalota;Ferguson, Kelly K.;Mukherjee, Bhramar;Calafat, Antonia M.;Crespo, Noe;Jimenez-Velez, Braulio;Padilla, Ingrid Y.;Alshawabkeh, Akram N.;Meeker, John D.
通讯作者：
Meeker, John D.
影响因子：
10.4
作者：
Chen H;Quandt SA;Grzywacz JG;Arcury TA
通讯作者：
Arcury TA
影响因子：
5
作者：
Deierlein AL;Ghassabian A;Kahn LG;Afanasyeva Y;Mehta-Lee SS;Brubaker SG;Trasande L
通讯作者：
Trasande L
影响因子：
11.8
作者：
Bloom, Michael S.;Wenzel, Abby G.;Newman, Roger B.
通讯作者：
Newman, Roger B.