Urinary phthalate metabolite concentrations among pregnant women in Northern Puerto Rico: distribution, temporal variability, and predictors.
Urinary phthalate metabolite concentrations among pregnant women in Northern Puerto Rico: distribution, temporal variability, and predictors.
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DOI：
10.1016/j.envint.2013.09.014
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发表时间：
2014-01
影响因子：
11.8
通讯作者：
Meeker, John D.
中科院分区：
文献类型：
--
作者：
Cantonwine, David E.;Cordero, Jose F.;Rivera-Gonzalez, Luis O.;Del Toro, Liza V. Anzalota;Ferguson, Kelly K.;Mukherjee, Bhramar;Calafat, Antonia M.;Crespo, Noe;Jimenez-Velez, Braulio;Padilla, Ingrid Y.;Alshawabkeh, Akram N.;Meeker, John D.
邻苯二甲酸盐污染存在于波多黎各北海岸岩溶含水层系统中。鉴于与邻苯二甲酸酯暴露相关的潜在健康影响，可能需要采取有针对性的行动消除暴露源，特别是对于孕妇等敏感人群。然而，缺乏关于波多黎各各种来源邻苯二甲酸酯暴露的信息。本研究的目的是确定居住在波多黎各北方喀斯特地区的女性在怀孕期间多次测量的尿邻苯二甲酸酯生物标志物的浓度和预测因子。我们在北方波多黎各招募了139名孕妇，并在三次单独访视（妊娠18±2周、22±2周和26±2周）时收集了尿液样本和问卷数据。分析尿样中的11种邻苯二甲酸酯代谢物：邻苯二甲酸单-2-乙基己酯（MEHP）、邻苯二甲酸单-2-乙基-5-羟己酯、邻苯二甲酸单-2-乙基-5-氧代己酯、邻苯二甲酸单-2-乙基-5-羧基戊酯、邻苯二甲酸单乙酯（MEP）、邻苯二甲酸单正丁酯、邻苯二甲酸单苄酯、邻苯二甲酸单异丁酯、邻苯二甲酸单-3-羧基丙酯（MCPP）、邻苯二甲酸单羧基异壬酯（MCNP）、和邻苯二甲酸单羧基异辛酯（MCOP）。在生活在波多黎各的孕妇中，邻苯二甲酸酯代谢物的可检测浓度普遍存在，代谢物浓度往往高于或类似于在美国一般人群的育龄妇女中测量的浓度。在所有邻苯二甲酸酯代谢物中，组内相关系数的范围为极弱（MCNP; 0.05）至中等（MEP; 0.44）重现性。我们观察到尿邻苯二甲酸酯代谢物浓度与水使用/储存习惯（MEP、MCNP、MCOP）、个人护理产品使用（MEP）和某些食物消耗（MCPP、MCNP和MCOP）之间存在显著或提示性正相关。据我们所知，这是第一项报告波多黎各孕妇邻苯二甲酸酯生物标志物浓度、时间变异性和预测因素的研究。初步结果表明，该人群中邻苯二甲酸酯的几个潜在重要暴露源，未来对该正在进行的前瞻性队列的分析将有助于为减少暴露的目标方法提供信息。
Phthalate contamination exists in the North coast karst aquifer system in Puerto Rico. In light of potential health impacts associated with phthalate exposure, targeted action for elimination of exposure sources may be warranted, especially for sensitive populations such as pregnant women. However, information on exposure to phthalates from a variety of sources in Puerto Rico is lacking. The objective of this study was to determine concentrations and predictors of urinary phthalate biomarkers measured at multiple times during pregnancy among women living in the Northern karst area of Puerto Rico. We recruited 139 pregnant women in Northern Puerto Rico and collected urine samples and questionnaire data at three separate visits (18±2 weeks, 22±2 weeks, and 26±2 weeks of gestation). Urine samples were analyzed for eleven phthalate metabolites: mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-hydroxyhexyl phthalate, mono-2-ethyl-5-oxohexyl phthalate, mono-2-ethyl-5-carboxypentyl phthalate, mono-ethyl phthalate (MEP), mono-n-butyl phthalate, mono-benzyl phthalate, mono-isobutyl phthalate, mono-3-carboxypropyl phthalate (MCPP), mono carboxyisononyl phthalate (MCNP), and mono carboxyisooctyl phthalate (MCOP). Detectable concentrations of phthalate metabolites among pregnant women living in Puerto Rico was prevalent, and metabolite concentrations tended to be higher than or similar to those measured in women of reproductive age from the general US population. Intraclass correlation coefficients ranged from very weak (MCNP; 0.05) to moderate (MEP; 0.44) reproducibility among all phthalate metabolites. We observed significant or suggestive positive associations between urinary phthalate metabolites concentrations and water usage/storage habits (MEP, MCNP, MCOP), use of personal care products (MEP), and consumption of certain food items (MCPP, MCNP, and MCOP). To our knowledge this is the first study to report concentrations, temporal variability, and predictors of phthalate biomarkers among pregnant women in Puerto Rico. Preliminary results suggest several potentially important exposure sources to phthalates in this population and future analysis from this ongoing prospective cohort will help to inform targeted approaches to reduce exposure.
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DOI：
10.1016/j.ijheh.2011.10.013
发表时间：
2012-02-01
影响因子：
6
作者：
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影响因子：
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