Circadian preference is associated with multiple domains of trait and state level impulsivity.

Circadian preference is associated with multiple domains of trait and state level impulsivity.
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DOI:
10.1080/07420528.2022.2035392
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发表时间:
2022-06
影响因子:
2.8
通讯作者:
Pedersen, Sarah L.
Pedersen, Sarah L.
中科院分区:
医学4区
文献类型:
--
作者:
Hasler, Brant P.;Wallace, Meredith L.;Graves, Jessica L.;Molina, Brooke S. G.;Pedersen, Sarah L.

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冲动性是一个多维度的结构,在特质和状态水平上都有充分记录的物质使用问题风险。对晚上的昼夜节律偏好与特质水平,整体冲动性有关,但这种关联是否在冲动性的多个维度上都成立,以及实际睡眠时间是否与冲动性平行相关仍不清楚。在这里,我们扩展现有的文献调查是否eveningness是与多个方面的特质和国家层面的冲动。我们还研究了这些协会利用睡眠时间和持续时间的日常措施,并探讨他们是否因性别和/或种族而异。所有参与者都是21-35岁的中度至重度社交饮酒者。主要分析包括78名参与者(100%白色男性参与者:样本1),具有昼夜节律偏好数据(早晨综合量表:CSM)和睡眠时间(睡眠中期)以及通过10天内每日自我报告评估的持续时间。通过UPPS-P评估冲动性的五个方面,包括基线(全量表;特质水平)和10天内每天最多6次(缩减量表;状态水平)。线性回归和混合效应模型被用来研究人与人之间的冲动与昼夜节律偏好,时间和持续时间的措施,占协变量的关联。探索性分析将样本1与额外的更多样化的样本(样本2)相结合,总共产生了182名参与者(29.1%自认为是黑人,29.7%为女性),每天自我报告睡眠时间和持续时间(没有昼夜节律偏好)。主要的人与人之间的模型发现,晚上与冲动的多个方面有关,在特质(缺乏毅力)和状态水平(消极和积极的紧迫感,缺乏毅力,缺乏预谋),而平均睡眠和持续时间通常与冲动无关。主要的人内模型在很大程度上掩盖了人与人之间的研究结果。对更大的组合样本1和2(没有昼夜节律偏好)的探索性分析发现,较晚的睡眠中时间与多个方面更大的平均状态水平冲动有关,这种关联可能因种族和性别而异。在一个样本的白色男性参与者,昼夜节律的偏好与多个方面的冲动,在特质和状态水平,这可能有助于风险的物质使用。初步研究结果表明,性别和种族差异的睡眠冲动协会,但未来的研究与客观的睡眠/昼夜节律措施在更大,更多样化的样本将是重要的,以澄清影响睡眠为重点的预防和/或治疗物质使用。
Impulsivity is a multidimensional construct with well-documented risk for substance use problems at both the trait- and state levels. A circadian preference towards eveningness has been linked to trait-level, global impulsivity, but whether this association holds true across multiple dimensions of impulsivity and whether actual sleep timing shows parallel associations with impulsivity remain unclear. Here, we extend existing literature by investigating whether eveningness is associated with multiple facets of both trait- and state-level impulsivity. We also examined these associations utilizing daily measures of sleep timing and duration and explored whether they differed by sex and/or race. All participants were moderate-to-heavy social drinkers aged 21–35. Primary analyses included 78 particiants (100% White male participants: Sample 1) with circadian preference data (Composite Scale of Morningness: CSM) and sleep timing (midsleep) and duration assessed via daily self-report over 10 days. Five facets of impulsivity were assessed via the UPPS-P, both at baseline (full scale; trait-level) and up to 6 times per day over 10 days (reduced scale; state-level). Linear regression and mixed-effects models were used to examine between- and within-person associations of impulsivity with measures of circadian preference, timing, and duration, accounting for covariates. Exploratory analyses combined Sample 1 with an additional more diverse sample (Sample 2), resulting in a total of 182 participaints (29.1% self-identified as Black, 29.7% as female) with daily self-report sleep timing and duration only (no circadian preference). Primary between-person models found that eveningness was associated with multiple facets of impulsivity, at trait (lack of perseverance) and state levels (negative and positive urgency, lack of perseverance, and lack of premeditation), while average midsleep and duration were generally unrelated to impulsivity. Primary within-person models largely paralleled the between-person findings. Exploratory analyses in the larger combined Samples 1 and 2 (without circadian preference) found that later midsleep timing was associated with greater mean state-level impulsivity across multiple facets, associations that may differ by race and sex. In a sample of White male participants, circadian preference for eveningness was strongly associated with multiple facets of impulsivity, at both trait- and state-levels, which may contribute to risk for substance use. Preliminary findings suggest sex and race differences in sleep-impulsivity associations, but future research with objective sleep/circadian measures in larger, more diverse samples will be important to clarify implications for sleep-focused prevention and/or treatment of substance use.
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