Effects of chronic manganese exposure on working memory in non-human primates.
Effects of chronic manganese exposure on working memory in non-human primates.
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DOI：
10.1016/j.brainres.2008.12.035
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发表时间：
2009-03-03
期刊：
影响因子：
2.9
通讯作者：
Guilarte TR
中科院分区：
文献类型：
--
作者：
Schneider JS;Decamp E;Clark K;Bouquio C;Syversen T;Guilarte TR
人体接触锰与多种认知缺陷有关，包括学习和记忆缺陷。然而，流行病学研究的结果在描述这种认知缺陷的性质方面并不一致。本研究旨在评估慢性锰暴露对非人类灵长类动物记忆功能的影响，并将行为结果与脑锰水平联系起来，试图解释先前研究中发现的结果变异性。在227.5±17.3天的时间内，对食蟹猕猴进行记忆相关任务（空间工作记忆、非空间工作记忆和参考记忆）的训练，并暴露于硫酸锰（15 ~ 20 mg/kg/周）中。血锰水平处于报告的人类环境、医疗或职业暴露水平的上限。在锰暴露期结束时，动物的空间工作记忆出现轻度缺陷，非空间工作记忆出现更严重缺陷，参考记忆没有缺陷。线性回归分析表明，在大多数脑区，工作记忆任务表现与脑锰浓度呈显著负相关。这些结果表明，在本研究中达到的长期暴露于锰水平可能对工作记忆产生有害影响，并且在几个大脑区域达到的锰水平与工作记忆表现呈负相关。
Human exposure to manganese has been associated with a variety of cognitive deficits including learning and memory deficits. However, results from epidemiological studies have been inconsistent in describing the nature of such cognitive deficits. The present study was conducted to evaluate the effects of chronic Mn exposure on memory functioning in non-human primates and to correlate behavioral outcome with brain Mn levels in an attempt to explain outcome variability seen in prior studies. Cynomolgus macaque monkeys were trained to perform memory-related tasks (spatial working memory, non-spatial working memory, reference memory) and exposed to manganese sulfate (15–20 mg/kg/week) over an exposure period lasting 227.5 ± 17.3 days. Blood manganese levels were in the upper range of levels reported for human environmental, medical or occupational exposures. By the end of the manganese exposure period, animals developed mild deficits in spatial working memory, more significant deficits in non-spatial working memory and no deficits in reference memory. Linear regression analyses showed that for most brain regions sampled, there was a significant inverse relationship between working memory task performance and brain Mn concentration. These results suggest that chronic exposure to levels of manganese achieved in this study may have detrimental effects on working memory and that Mn levels achieved in several brain regions are inversely related to working memory performance.
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