Severe fatigue and related factors in cancer patients before the initiation of treatment.
Severe fatigue and related factors in cancer patients before the initiation of treatment.
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DOI：
10.1038/sj.bjc.6604739
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发表时间：
2008-11-04
影响因子：
8.8
通讯作者：
Bleijenberg G
中科院分区：
文献类型：
--
作者：
Goedendorp MM;Gielissen MF;Verhagen CA;Peters ME;Bleijenberg G
众所周知，疲劳是癌症治疗期间和癌症幸存者的常见症状。然而，在癌症诊断后，在癌症治疗开始之前，从未研究过疲劳。本研究调查了癌症患者在开始治疗前严重疲劳的患病率及其相关因素。179例各种恶性肿瘤患者在开始治疗前进行了评估，包括检查表个人力量，疾病影响概况，Beck抑郁量表初级护理，症状检查表-90和6个数字评定量表，以测量疲劳，疼痛和体力活动。为了测试哪些因素导致严重疲劳，进行了逻辑回归分析。总共有23.5%的患者严重疲劳，不同的诊断不同;前列腺癌（14.3%），乳腺癌（20.3%）和胃肠道癌（28.1%）。目前较低的体力活动（P = 0.013），更多的抑郁情绪（P = 0.014），在白天和晚上的睡眠和休息受损（P = 0.045），疲劳1年前诊断（P = 0.005）有助于严重疲劳。相对大量的癌症患者在开始治疗之前已经经历了严重的疲劳，在14 - 28%之间变化。在这个阶段导致严重疲劳的因素是体力活动，抑郁情绪，睡眠和休息受损，以及诊断前1年的疲劳。
It is generally known that fatigue is a common symptom during cancer treatment, and in cancer survivors. However, fatigue was never studied after diagnosis, before cancer treatment was initiated. This study investigated the prevalence of severe fatigue, and related factors, in cancer patients before the initiation of treatment. One hundred and seventy-nine patients with various malignancies were assessed before start of treatment with curative intention, including the Checklist Individual Strength, Sickness Impact Profile, Beck Depression Inventory Primary Care, Symptom Checklist-90, and six Numeric Rating Scales to measure fatigue, pain and physical activity. To test which factors contributed to severe fatigue a logistic regression analysis was performed. In total 23.5% patients were severely fatigued, varying between diagnoses; prostate cancer (14.3%), breast cancer (20.3%), and gastrointestinal cancer (28.1%). Currently lower physical activity (P=0.013), more depressive mood (P=0.014), impaired sleep and rest during the day and night (P=0.045), and fatigue 1 year before diagnosis (P=0.005) contributed to severe fatigue. Relatively large numbers of cancer patients already experience severe fatigue before initiation of treatment, varying between 14–28%. The factors that contributed to severe fatigue at this stage were physical activity, depressive mood, impaired sleep and rest, and fatigue 1 year before diagnosis.
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影响因子：
3
作者：
BERGNER, M;BOBBITT, RA;GILSON, BS
通讯作者：
GILSON, BS
影响因子：
0.3
作者：
Bartsch, HH;Weis, J;Moser, MT
通讯作者：
Moser, MT
影响因子：
3.8
作者：
Beck, AT;Steer, RA;Kabat, M
通讯作者：
Kabat, M
影响因子：
4.2
作者：
JACOBSEN, PB;BOVBJERG, DH;REDD, WH
通讯作者：
REDD, WH
影响因子：
50.5
作者：
Dimeo, F;Stieglitz, RD;Keul, J
通讯作者：
Keul, J