A tree‐parenchyma coupled model for lung ventilation simulation
A tree‐parenchyma coupled model for lung ventilation simulation
复制标题
用于肺通气模拟的树-实质耦合模型
DOI：
10.1002/cnm.2873
复制
发表时间：
2017
影响因子：
2.1
通讯作者：
Céline Grandmont
中科院分区：
文献类型：
--
作者：
N. Pozin;S. Montesantos;I. Katz;M. Pichelin;I. Vignon;Céline Grandmont
在本文中，我们建立了一个肺通气模型。薄壁组织被描述为弹性均匀介质。它是由一个空间填充的二元电阻管网，代表气管支气管树灌溉。在这个模型中，树和薄壁组织是强耦合的。树诱导系统的本构关系，这导致，在有限元框架中，一个完整的矩阵中的额外的粘性项。我们考虑一种有效的算法，它利用树结构来实现快速矩阵-向量积计算。该框架可用于模拟健康和疾病中的自由和机械诱导呼吸。考虑从计算机断层扫描中获得的患者特定肺部几何形状。现实的Dirichlet边界条件可以从计算机断层扫描图像上的表面配准推导出来。该模型相比，一个更经典的出口车厢的方法。结果说明了树和薄壁组织之间的耦合，在全球和区域层面上，以及如何可以推断出纯0 D模型的条件。不同类型的边界条件进行了测试，包括周围的肺结构的非线性罗宾模型。
In this article, we develop a lung ventilation model. The parenchyma is described as an elastic homogenized media. It is irrigated by a space‐filling dyadic resistive pipe network, which represents the tracheobronchial tree. In this model, the tree and the parenchyma are strongly coupled. The tree induces an extra viscous term in the system constitutive relation, which leads, in the finite element framework, to a full matrix. We consider an efficient algorithm that takes advantage of the tree structure to enable a fast matrix‐vector product computation. This framework can be used to model both free and mechanically induced respiration, in health and disease. Patient‐specific lung geometries acquired from computed tomography scans are considered. Realistic Dirichlet boundary conditions can be deduced from surface registration on computed tomography images. The model is compared to a more classical exit compartment approach. Results illustrate the coupling between the tree and the parenchyma, at global and regional levels, and how conditions for the purely 0D model can be inferred. Different types of boundary conditions are tested, including a nonlinear Robin model of the surrounding lung structures.
影响因子：
3.3
作者：
Tawhai, MH;Hunter, P;Hoffman, EA
通讯作者：
Hoffman, EA
影响因子：
2.4
作者：
Oakes JM;Marsden AL;Grandmont C;Darquenne C;Vignon-Clementel IE
通讯作者：
Vignon-Clementel IE
影响因子：
2.4
作者：
Yin, Youbing;Choi, Jiwoong;Hoffman, Eric A.;Tawhai, Merryn H.;Lin, Ching-Long
通讯作者：
Lin, Ching-Long