Simulation of pulmonary air flow with a subject-specific boundary condition.

Simulation of pulmonary air flow with a subject-specific boundary condition.
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DOI:
10.1016/j.jbiomech.2010.03.048
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发表时间:
2010-08-10
影响因子:
2.4
通讯作者:
Lin, Ching-Long
Lin, Ching-Long
中科院分区:
工程技术3区
文献类型:
--
作者:
Yin, Youbing;Choi, Jiwoong;Hoffman, Eric A.;Tawhai, Merryn H.;Lin, Ching-Long

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我们提出了一种新的基于图像的技术来估计特定于受试者的边界条件(BC)的计算流体动力学(CFD)模拟肺气流。通过配准两个计算机断层扫描(CT)肺数据集来导出个体的局部通气的信息,然后将其作为流量BC传递到CT分辨的气道。计算流体力学模拟表明,所提出的方法预测肺叶体积变化与直接图像测量指标一致,而其他两个传统的BC(均匀速度或均匀压力)产生肺叶体积变化和区域压力差与观察到的生理不一致。
We present a novel image-based technique to estimate a subject-specific boundary condition (BC) for computational fluid dynamics (CFD) simulation of pulmonary air flow. The information of regional ventilation for an individual is derived by registering two computed tomography (CT) lung datasets and then passed to the CT-resolved airways as the flow BC. The CFD simulations show that the proposed method predicts lobar volume changes consistent with direct image-measured metrics, whereas the other two traditional BCs (uniform velocity or uniform pressure) yield lobar volume changes and regional pressure differences inconsistent with observed physiology.
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