The genesis and source of the H7N9 influenza viruses causing human infections in China.
The genesis and source of the H7N9 influenza viruses causing human infections in China.
复制标题
作者：
自2013年3月首次发现一种新型H7N9甲型流感病毒以来，已导致中国130多人感染，导致40人死亡。初步分析表明，该病毒是H7、N9和H9N2型禽流感病毒的重新配型，并携带一些与哺乳动物受体结合相关的氨基酸，引发了人们对新一轮大流行的担忧。然而，H7N9疫情谱系的来源人群和其发生的条件都不完全清楚。利用主动监测、病毒档案筛选和进化分析相结合的方法，我们在这里表明，H7病毒可能至少在两次独立的情况下从中国的家鸭传播到鸡群。我们发现，H7病毒随后与地方性H9N2病毒重新配对，产生了H7N9暴发谱系，以及相关的以前未被识别的H7N7谱系。H7N9疫情谱系已经蔓延到一个很大的地理区域，并在活禽市场的鸡只中流行，活禽市场被认为是人类感染的直接来源。H7N9疫情谱系是否已经或将在中国及邻近地区成为地方性流行病，需要进一步调查。这里在鸡身上发现了一种相关的H7N7流感病毒，它有能力通过实验感染哺乳动物，这表明H7病毒可能会构成当前疫情以外的威胁。H7病毒在家禽中的持续流行可能导致高致病性变种的产生和进一步的零星人类感染，并继续存在病毒获得人传人的风险。
A novel H7N9 influenza A virus first detected in March 2013 has since caused more than 130 human infections in China, resulting in 40 deaths,. Preliminary analyses suggest that the virus is a reassortant of H7, N9 and H9N2 avian influenza viruses, and carries some amino acids associated with mammalian receptor binding, raising concerns of a new pandemic,,. However, neither the source populations of the H7N9 outbreak lineage nor the conditions for its genesis are fully known. Using a combination of active surveillance, screening of virus archives, and evolutionary analyses, here we show that H7 viruses probably transferred from domestic duck to chicken populations in China on at least two independent occasions. We show that the H7 viruses subsequently reassorted with enzootic H9N2 viruses to generate the H7N9 outbreak lineage, and a related previously unrecognized H7N7 lineage. The H7N9 outbreak lineage has spread over a large geographic region and is prevalent in chickens at live poultry markets, which are thought to be the immediate source of human infections. Whether the H7N9 outbreak lineage has, or will, become enzootic in China and neighbouring regions requires further investigation. The discovery here of a related H7N7 influenza virus in chickens that has the ability to infect mammals experimentally, suggests that H7 viruses may pose threats beyond the current outbreak. The continuing prevalence of H7 viruses in poultry could lead to the generation of highly pathogenic variants and further sporadic human infections, with a continued risk of the virus acquiring human-to-human transmissibility.
登录
查看更多内容
影响因子：
6.5
作者：
Anisimova M;Gil M;Dufayard JF;Dessimoz C;Gascuel O
通讯作者：
Gascuel O
人类感染新型禽源甲型流感 (H7N9) 病毒。
影响因子：
158.5
作者：
Gao, Rongbao;Cao, Bin;Shu, Yuelong
通讯作者：
Shu, Yuelong
影响因子：
64.5
作者：
Tharakaraman K;Jayaraman A;Raman R;Viswanathan K;Stebbins NW;Johnson D;Shriver Z;Sasisekharan V;Sasisekharan R
通讯作者：
Sasisekharan R
影响因子：
5.4
作者：
Cheung, C. L.;Vijaykrishna, D.;Guan, Y.
通讯作者：
Guan, Y.
影响因子：
9.8
作者：
Drummond AJ;Ho SY;Phillips MJ;Rambaut A
通讯作者：
Rambaut A