Human neonatal leukocyte interferon production and natural killer cytotoxicity in response to herpes simplex virus.
Human neonatal leukocyte interferon production and natural killer cytotoxicity in response to herpes simplex virus.
复制标题
人类新生儿白细胞干扰素的产生和自然杀伤细胞毒性对单纯疱疹病毒的反应。
DOI:
10.1089/jir.1983.3.461
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发表时间:
1983
期刊:
影响因子:
--
通讯作者:
Harmon,MW
中科院分区:
文献类型:
--
作者:
Kohl,S;Harmon,MW
Human neonates are susceptible to severe herpes simplex virus (HSV) infection; however, the immunologic mechanisms explaining this lack of resistance remain to be defined. The ability of leukocytes from adults and neonates to produce interferon (IFN) in response to HSV challenge and to destroy HSV infected cells in the absence of antibody, termed natural killer cytotoxicity (NKC), were compared. The NKC activity of leukocytes from neonates (13.5 ± 2.5%) was significantly lower (p < 0.005, Mann Whitney test; p = 0.007, Students t-test) than the NKC activity of adult leukocytes (25.7 ± 3.2%). In contrast, no significant difference was observed between IFN production by neonate (87.7 ± 29.1 units) and adult (87.8 ± 29.4 units) leukocytes.
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影响因子:
3.1
作者:
C. Garzelli;V. Colizzi;M. Campa;L. Bozzi;G. Falcone
通讯作者:
G. Falcone
DOI:
10.1016/s0022-3476(81)80699-3
发表时间:
1981
期刊:
The Journal of pediatrics
影响因子:
--
作者:
Kohl,S;Frazier,JJ;Greenberg,SB;Pickering,LK;Loo,LS
通讯作者:
Loo,LS
DOI:
--
发表时间:
1971
期刊:
影响因子:
--
作者:
L. W. Catalano;G. H. Safley;M. Museles;D. J. Jarzynski
通讯作者:
D. J. Jarzynski
影响因子:
3.3
作者:
S. Kohl;S. S. Shaban;S. Starr;P. Wood;A. Nahmias
通讯作者:
A. Nahmias
影响因子:
3.1
作者:
M. Harmon;S. Greenberg;P. E. Johnson;R. Couch
通讯作者:
R. Couch