Impact of prednisone on TGF‐β1 and collagen in diaphragm muscle from mdx mice
Impact of prednisone on TGF‐β1 and collagen in diaphragm muscle from mdx mice
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泼尼松对 mdx 小鼠膈肌中 TGF-β1 和胶原蛋白的影响
作者：
J. Hartel;J. Granchelli;M. S. Hudecki;C. Pollina;L. Gosselin
本研究的目的是评估泼尼松治疗8周对12周龄mdx小鼠膈肌中转化生长因子β 1（TGF-β1）水平、羟脯氨酸（HYP）浓度和成熟不可还原胶原交联羟赖氨酰吡啶啉（HP）水平的影响。与正常C57 BL/10 J（对照）小鼠相比，未处理mdx小鼠的膈肌具有显著更高水平的TGF-β1、HYP和HP交联。泼尼松治疗显著降低mdx小鼠膈肌中TGF-β1和HYP水平至与对照小鼠相似的值，但与未治疗的mdx小鼠相比，导致更高水平的HP交联。这些结果表明，用泼尼松短期治疗mdx小鼠可以减轻膈肌中的纤维化反应，可能是通过介导TGF-β的水平。尽管泼尼松在预防胶原蛋白积聚方面是有益的，但其可能通过减少胶原蛋白周转而导致更高水平的HP交联© 2001 John Wiley & Sons，Inc.肌肉神经24：428-432，2001
The purpose of this study was to assess the impact of prednisone treatment for 8 weeks on the level of transforming growth factor‐beta 1 (TGF‐β1), hydroxyproline (HYP) concentrations, and level of the mature, nonreducible collagen cross‐link hydroxylysylpyridinoline (HP) in diaphragm muscle from 12‐week‐old mdx mice. Diaphragm muscle from untreated mdx mice had a significantly higher level of TGF‐β1, HYP, and HP cross‐link compared with normal C57BL/10J (control) mice. Prednisone treatment significantly reduced the level of TGF‐β1 and HYP in diaphragm from mdx mice to values similar to control mice, but resulted in a higher level of the HP cross‐link compared with untreated mdx mice. These findings indicate that short‐term treatment of mdx mice with prednisone can attenuate the fibrotic response in diaphragm muscle, possibly by mediating the level of TGF‐β. Although prednisone was beneficial in preventing collagen accumulation, it resulted in a higher level of the HP cross‐link, presumably by decreasing collagen turnover © 2001 John Wiley & Sons, Inc. Muscle Nerve 24: 428–432, 2001
DOI：
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发表时间：
1986-03
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
R. Ignotz;J. Massagué
通讯作者：
R. Ignotz;J. Massagué
营养不良小鼠膈肌肌球蛋白重链表达和收缩功能的适应。
DOI：
10.1152/ajpcell.1993.265.3.c834
发表时间：
1993
期刊：
The American journal of physiology
影响因子：
--
作者：
Petrof,BJ;Stedman,HH;Shrager,JB;Eby,J;Sweeney,HL;Kelly,AM
通讯作者：
Kelly,AM
影响因子：
2.9
作者：
CHEUNG, DT;NIMNI, ME
通讯作者：
NIMNI, ME