Peptide targeting of mitochondria elicits testosterone formation.
Peptide targeting of mitochondria elicits testosterone formation.
复制标题
线粒体肽靶向引发睾酮形成。
DOI：
10.1038/mt.2014.171
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Campanella M
中科院分区：
文献类型：
--
作者：
Campanella M
睾酮（T）是雄性脊椎动物生殖系统生长发育的主要性激素。由于其对心理和行为的影响，它不仅受到医学和科学界的广泛关注，而且也受到公众的广泛关注。3 T驱动着几个生物过程的不对称性，这些生物过程包括男性化、男性化、疾病预防、1和衰老。4在本期《分子治疗》中，Aghazadeh等人5描述了一种新的融合肽TVS 167，它可以诱导大鼠睾丸中T的形成，增加其血清水平，并在暴露于促性腺激素释放激素拮抗剂的成年雄性大鼠中挽救其合成，促性腺激素释放激素拮抗剂构成了下丘脑-垂体-性腺轴控制T产生的初始步骤。该肽通过利用线粒体转导体内电压依赖性阴离子通道1（VDAC 1）和18 kDa转运蛋白（TSPO）之间的相互作用发挥作用，线粒体转导体是一种控制脂质输入和类固醇生成的多组分分子机器。该肽揭示了类固醇激素的线粒体途径中的调节机制，其可以提供用于治疗干预的新靶点（参见中的模型）。
Testosterone (T) is the principal sex hormone responsible for growth and development of the reproductive system in male vertebrates. 1 It has historically received much attention not only from the medical and scientific communities2 but also from the general public, owing to its psychological and behavioral effects. 3 T drives the asymmetry of several biological processes spanning virilization to anabolism, disease prevention, 1 and aging. 4 In this issue of Molecular Therapy, Aghazadeh et al. 5 describe a novel fusion peptide, TVS167, that can induce T formation in rat testes and increase its serum level as well as rescue its synthesis in adult male rats exposed to antagonists of the gonadotropin-releasing hormone, which constitutes the initial step in the hypothalamic–pituitary–gonadal axis governing T production. This peptide acts by exploiting the interaction between the voltage-dependent anion channel 1 (VDAC1) and the 18-kDa translocator protein (TSPO) within the mitochondrial transduceosome, a multicomponent molecular machine that controls lipid import and steroidogenesis. This peptide reveals a regulatory mechanism in the mitochondrial pathway of steroid anabolism that could provide a new target for therapeutic intervention (see model in
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DOI：
10.1080/13685530802699067
发表时间：
2009-03
期刊：
The aging male : the official journal of the International Society for the Study of the Aging Male
影响因子：
--
作者：
Carruthers M
通讯作者：
Carruthers M
影响因子：
4.1
作者：
Papadopoulos, Vassilios;Liu, Jun;Culty, Martine
通讯作者：
Culty, Martine
DOI：
10.1073/pnas.94.14.7537
发表时间：
1997-07-08
影响因子：
11.1
作者：
Morley, JE;Kaiser, F;Roberts, E
通讯作者：
Roberts, E
DOI：
10.1097/00005392-200102000-00004
发表时间：
2001
期刊：
The Journal of urology
影响因子：
--
作者：
Erica R. Freeman;D. Bloom;E. Mcguire
通讯作者：
E. Mcguire