Is depression an inflammatory disorder?
Is depression an inflammatory disorder?
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DOI：
10.1007/s11920-011-0232-0
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发表时间：
2011-12
影响因子：
6.7
通讯作者：
Miller, Andrew H.
中科院分区：
文献类型：
--
作者：
Raison, Charles L.;Miller, Andrew H.
关键词：
研究一直表明，与非抑郁个体组相比，患有重度抑郁症（MDD）的个体组多种外周炎症生物标志物水平升高。这些发现通常被解读为，即使在身体健康的个体中，MDD也可能是一种炎症性疾病。在本文中，我们通过更仔细地研究炎症发现的实际模式在MDD与免疫系统之间的关系方面所表明的情况，来检验支持和反对这一观点的证据。文中提供的数据支持这样一种观点，即炎症仅在一部分患者中导致抑郁，而非炎症激活的致抑郁作用更为普遍且因任何给定个体在已知与MDD病因相关的相互关联的生理系统中所表现出的脆弱程度不同而有所差异。最后，讨论了这些不同可能性的治疗意义。
Studies consistently report that groups of individuals with major depressive disorder (MDD) demonstrate increased levels of a variety of peripheral inflammatory biomarkers when compared with groups of nondepressed individuals. These findings are often interpreted as meaning that MDD, even in medically healthy individuals, may be an inflammatory condition. In this article, we examine evidence for and against this idea by looking more closely into what the actual patterns of inflammatory findings indicate in terms of the relationship between MDD and the immune system. Data are presented in support of the idea that inflammation only contributes to depression in a subset of patients versus the possibility that the depressogenic effect of inflammatory activation is more widespread and varies depending on the degree of vulnerability any given individual evinces in interconnected physiologic systems known to be implicated in the etiology of MDD. Finally, the treatment implications of these various possibilities are discussed.
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