Advances in Our Understanding of the Mechanism of Action of Drugs (including Traditional Chinese Medicines) for the Intervention and Treatment of Osteoporosis.
Advances in Our Understanding of the Mechanism of Action of Drugs (including Traditional Chinese Medicines) for the Intervention and Treatment of Osteoporosis.
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我们对用于骨质疏松症干预与治疗的药物（包括中药）作用机制认识的进展
DOI：
10.3389/fphar.2022.938447
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发表时间：
2022
影响因子：
5.6
通讯作者：
Shuai, Bo
中科院分区：
文献类型：
--
作者：
Lu, Junjie;Hu, Desheng;Ma, Chen;Shuai, Bo
骨质疏松症（OP）是一种无症状的疾病，其中骨量和骨密度的损失不会引起明显的症状，导致治疗和预防措施不足。随着时间的推移，骨量和骨密度的损失变得更加严重，只有一小部分患者在发生OP相关骨折时被诊断出来。OP相关骨折的致残率和死亡率高，造成严重的身心伤害，给个人和社会带来沉重的经济负担。因此，必须强调早期干预和治疗，以达到降低骨折风险的总体目标。抗OP药物目前分为三类：抗吸收剂、合成代谢剂和具有其他机制的药物。本文就这三类常用抗OP药物及其靶向治疗的研究进展进行综述，以帮助研究者和临床医生了解其作用机制，促进药理学研究和新药开发。
Osteoporosis (OP) is known as a silent disease in which the loss of bone mass and bone density does not cause obvious symptoms, resulting in insufficient treatment and preventive measures. The losses of bone mass and bone density become more severe over time and an only small percentage of patients are diagnosed when OP-related fractures occur. The high disability and mortality rates of OP-related fractures cause great psychological and physical damage and impose a heavy economic burden on individuals and society. Therefore, early intervention and treatment must be emphasized to achieve the overall goal of reducing the fracture risk. Anti-OP drugs are currently divided into three classes: antiresorptive agents, anabolic agents, and drugs with other mechanisms. In this review, research progress related to common anti-OP drugs in these three classes as well as targeted therapies is summarized to help researchers and clinicians understand their mechanisms of action and to promote pharmacological research and novel drug development.
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影响因子：
20.3
作者：
Bouillon R;Marcocci C;Carmeliet G;Bikle D;White JH;Dawson-Hughes B;Lips P;Munns CF;Lazaretti-Castro M;Giustina A;Bilezikian J
通讯作者：
Bilezikian J
影响因子：
3.9
作者：
Alves Nunes, Rita de Cassia;Chiba, Fernando Yamamoto;Sumida, Doris Hissako
通讯作者：
Sumida, Doris Hissako
影响因子：
15.9
作者：
Ammann, P;Rizzoli, R;Garcia, I
通讯作者：
Garcia, I
影响因子：
4.8
作者：
BEUTNER, EH;MUNSON, PL
通讯作者：
MUNSON, PL
影响因子：
4.8
作者：
Armbrecht, HJ;Hodam, TL;Kumar, VB
通讯作者：
Kumar, VB