Transcriptional Coactivators: Driving Force of Plant Immunity.
Transcriptional Coactivators: Driving Force of Plant Immunity.
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转录共激活因子：植物免疫的驱动力。
DOI：
10.3389/fpls.2022.823937
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发表时间：
2022
影响因子：
5.6
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Khan MSS;Islam F;Chen H;Chang M;Wang D;Liu F;Fu ZQ;Chen J
水杨酸（SA）是一种植物防御信号，可介导针对病原体入侵的局部和全身免疫反应。然而，SA 介导的防御的潜在机制非常复杂，因为涉及各种正负调节因子来微调其在不同病理系统中的信号传导。病原体感染后，SA 水平升高会促进大规模转录重编程，其中 PR 基因非表达蛋白 1 (NPR1) 在防御反应中充当中枢和转录共激活因子。最近的研究结果表明，增强疾病易感性 1 (EDS1) 还具有转录共激活因子的功能，并在 NPR1 和 SA 存在的情况下刺激 PR1 的表达。此外，EDS1 稳定 NPR1 蛋白水平，而 NPR1 在病原感染期间维持 EDS1 表达。 NPR1 和 EDS1 共激活剂的相互作用通过在介体复合物中招募细胞周期蛋白依赖性激酶 8 来启动转录重编程，以控制免疫反应。在这篇综述中，我们重点介绍了最近取得的突破，这些突破极大地增进了我们对转录共激活因子如何与其功能伙伴相互作用以触发不同途径以促进免疫反应，以及 SA 积累如何诱导 NPR1 结构动态变化以进行转录重编程的理解。此外，还根据最近的发现讨论了不同介导亚基在SA介导的植物免疫中的功能。总而言之，现有证据表明转录共激活子是植物防御途径的重要且有效的调节剂，并且在植物与病原体相互作用期间协调植物免疫反应中发挥着至关重要的作用。
Salicylic acid (SA) is a plant defense signal that mediates local and systemic immune responses against pathogen invasion. However, the underlying mechanism of SA-mediated defense is very complex due to the involvement of various positive and negative regulators to fine-tune its signaling in diverse pathosystems. Upon pathogen infections, elevated level of SA promotes massive transcriptional reprogramming in which Non-expresser of PR genes 1 (NPR1) acts as a central hub and transcriptional coactivator in defense responses. Recent findings show that Enhanced Disease Susceptibility 1 (EDS1) also functions as a transcriptional coactivator and stimulates the expression of PR1 in the presence of NPR1 and SA. Furthermore, EDS1 stabilizes NPR1 protein level, while NPR1 sustains EDS1 expression during pathogenic infection. The interaction of NPR1 and EDS1 coactivators initiates transcriptional reprogramming by recruiting cyclin-dependent kinase 8 in the Mediator complex to control immune responses. In this review, we highlight the recent breakthroughs that considerably advance our understanding on how transcriptional coactivators interact with their functional partners to trigger distinct pathways to facilitate immune responses, and how SA accumulation induces dynamic changes in NPR1 structure for transcriptional reprogramming. In addition, the functions of different Mediator subunits in SA-mediated plant immunity are also discussed in light of recent discoveries. Taken together, the available evidence suggests that transcriptional coactivators are essential and potent regulators of plant defense pathways and play crucial roles in coordinating plant immune responses during plant–pathogen interactions.
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影响因子：
6.7
作者：
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通讯作者：
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通讯作者：
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