The ciliary membrane.

The ciliary membrane.
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DOI:
10.1016/j.ceb.2010.03.010
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发表时间:
2010-08
影响因子:
7.5
通讯作者:
Snell, William J.
Snell, William J.
中科院分区:
生物学2区
文献类型:
--
作者:
Rohatgi, Rajat;Snell, William J.

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纤毛和鞭毛在发育和疾病中都是重要的信号组织中心。其功能的关键是其基部的功能屏障特征不明确,其允许睫状体膜的蛋白质和脂质组成与质膜的蛋白质和脂质组成不同。我们回顾了目前的模型上的生物发生的睫状膜,突出几个结构,包括睫状项链和睫状口袋,出现在生物发生过程中,可能有助于屏障。膜蛋白和脂质跨越这一屏障的调节运动是这些细胞器的感觉功能的核心。
Cilia and flagella function as important organizing centers for signaling in both development and disease. A key to their function is a poorly characterized functional barrier at their base that allows the protein and lipid composition of the ciliary membrane to be distinct from that of the plasma membrane. We review current models on the biogenesis of the ciliary membrane, highlighting several structures, including the ciliary necklace and ciliary pocket, that appear during biogenesis and that likely contribute to the barrier. The regulated movement of membrane proteins and lipids across this barrier is central to the sensory function of these organelles.
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