The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation.

The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation.
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DOI:
10.1186/gb-2009-10-4-r40
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发表时间:
2009
期刊:
影响因子:
12.3
通讯作者:
Daub CO
Daub CO
中科院分区:
生物学1区
文献类型:
--
作者:
Kawaji H;Severin J;Lizio M;Waterhouse A;Katayama S;Irvine KM;Hume DA;Forrest AR;Suzuki H;Carninci P;Hayashizaki Y;Daub CO

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FANTOM4合作研究项目收集的基因组尺度数据作为一个集成的网络资源呈现。在国际合作研究项目FANTOM4中,我们收集了广泛的基因组尺度数据,包括沿人类THP-1细胞系分化时间过程和52个系统siRNA扰动下的2400万个mRNA 5'-reads (CAGE标签)和微阵列表达谱。此外,从ChIP-chip获得的染色质状态数据阐明了转录调控相互作用。在这里,我们将这些数据作为一个综合的网络资源呈现给研究社区。
The genome-scale data collected by the FANTOM4 collaborative research project are presented as an integrated web resource. In FANTOM4, an international collaborative research project, we collected a wide range of genome-scale data, including 24 million mRNA 5'-reads (CAGE tags) and microarray expression profiles along a differentiation time course of the human THP-1 cell line and under 52 systematic siRNA perturbations. In addition, data regarding chromatin status derived from ChIP-chip to elucidate the transcriptional regulatory interactions are included. Here we present these data to the research community as an integrated web resource.
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