Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats.
Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats.
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黄芩苷影响慢性应激大鼠海马新生神经元树突形态
DOI：
10.3969/j.issn.1673-5374.2013.06.002
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发表时间：
2013-02-25
影响因子：
6.1
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Jiang X;Xu J;Zou D;Yang L;Wang Y
采用皮下注射皮质酮40 mg/kg，每日1次，连续14 d建立慢性应激大鼠模型，每日灌胃黄芩苷50 mg/kg。本研究旨在观察黄芩苷对慢性应激大鼠神经发生的影响。结果表明，皮下注射皮质酮可显著减少海马内doublecortin阳性神经元的总数。皮质酮引起的细胞数量减少主要是由于II类Doublecortin阳性神经元减少，而I类Doublecortin阳性神经元不受影响。黄芩苷处理增加了I类和II类doublecortin阳性神经元的数量。此外，皮质酮注射后，doublecortin阳性神经元树突形态的复杂性降低，黄芩苷治疗后，这种变化完全逆转。这些发现表明黄芩苷对成人神经发生具有有益的作用。
Chronic stress models, established in adult Sprague-Dawley rats through a 14-day subcutaneous injection of 40 mg/kg corticosterone, once per day, were given a daily oral feeding of 50 mg/kg baicalin. The study was an attempt to observe the effect of baicalin on neurogenesis in chronically stressed rats. Results showed that subcutaneous injection of corticosterone significantly decreased the total number of doublecortin-positive neurons in the hippocampus. The reduced cell number caused by corticosterone was mainly due to the decrease of class II doublecortin-positive neurons, but the class I doublecortin-positive neurons were unaffected. Baicalin treatment increased the number of both class I and class II doublecortin-positive neurons. In addition, doublecortin-positive neurons showed less complexity in dendritic morphology after corticosterone injection, and this change was totally reversed by baicalin treatment. These findings suggest that baicalin exhibits a beneficial effect on adult neurogenesis.
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影响因子：
82.9
作者：
Eriksson, PS;Perfilieva, E;Gage, FH
通讯作者：
Gage, FH
影响因子：
2.5
作者：
Brown, JP;Couillard-Després, S;Kuhn, HG
通讯作者：
Kuhn, HG
影响因子：
2.5
作者：
Huang, Zhen;Zhong, Xiao-Ming;Mao, Qing-Qiu
通讯作者：
Mao, Qing-Qiu
影响因子：
8.3
作者：
Komitova, M;Mattsson, B;Eriksson, PS
通讯作者：
Eriksson, PS
影响因子：
3.3
作者：
Brummelte, S.;Galea, L. A. M.
通讯作者：
Galea, L. A. M.