Run, jump, and be merry: how much exercise is needed for building young bones?
Run, jump, and be merry: how much exercise is needed for building young bones?
复制标题
DOI：
10.1002/jbmr.2264
复制
发表时间：
2014-06
影响因子：
6.2
通讯作者：
Gordon, Catherine M.
中科院分区：
文献类型：
--
作者：
Gordon, Catherine M.
定期的负重体力活动对于强健骨骼的发育至关重要。这一概念在儿童和青少年时期尤其重要，因为超过一半的峰值骨量是在青少年时期积累的，伴随着第二性征的发育和青春期的快速生长。(1)在动物和人体模型中，与运动相关的骨骼负荷也显示出增加骨骼尺寸和强度，从而促进结构优化骨骼的发展，（2-4）临床试验数据支持运动对骨骼的益处，特别是在生长期。(5-7)然而，运动处方，产生最佳的骨骼增长和骨骼强度的儿童骨骼是未知的。因此，Detter及其同事（8）在本期《骨与矿物质研究杂志》上发表的文章是及时的，也是非常有意义的。Detter及其同事（8）的研究设计优雅，使用的数据来自一项前瞻性、基于人群的对照运动干预研究，结果包括骨折、骨量和结构。马尔莫儿童骨质疏松症预防（POP）研究采集了干预组417名女孩和500名男孩以及对照组835名女孩和869名男孩的数据，每个女孩和男孩在研究开始时年龄为6至9岁。这些孩子就读于瑞典四所邻近的小学，来自中产阶级的社会经济地位，每所学校都是政府资助的，必须使用强制性的标准瑞典体育课程。虽然代表了一个方便的样本，但研究的这些方面值得注意，因为基线时体力活动的变异性较小。这四所学校的规模也相似，这一点很重要，因为在目前的运动干预试验中，治疗是如何分配的。四所学校中的一所作为干预学校参加，其他三所作为对照学校。评估了所有参与者的骨折发生率。重要的是，采用了一个复杂的监测系统，所有骨折都通过X线片进行了验证。6年期间的骨折记录在医院的放射学档案和计算机化数据库中，该数据库包括在瑞典南部获得的所有X线照片。由于该市只有一家急诊医院，几乎所有的骨折都被捕获，这是一个独特的系统，以前曾被证明错过了不到3%的持续骨折。
Regular weight‐bearing physical activity is essential for the development of a strong and healthy skeleton. This concept is of particular importance during childhood and adolescence, because over half of peak bone mass is accrued during the teenage years, accompanying the development of secondary sexual characteristics and the pubertal growth spurt.(1) The skeletal loading associated with exercise has also been shown in both animal and human models to augment bone size and strength, thus facilitating the development of a structurally optimized skeleton,(2–4) and data from clinical trials support the skeletal benefits of exercise, particularly during periods of growth.(5–7) However, the exercise prescription that yields optimal bone accrual and skeletal strength for the pediatric skeleton is unknown. Thus, the article of Detter and colleagues (8) in this issue of the Journal of Bone and Mineral Research is timely and of high interest.The study of Detter and colleagues (8) was elegantly designed, using data from a prospective, population‐based, controlled exercise intervention study with incident fractures, and bone mass and structure as outcomes. The Malmo Pediatric Osteoporosis Prevention (POP) Study captured data from 417 girls and 500 boys in their intervention group and 835 girls and 869 boys in the control group, each age 6 to 9 years at study entry. The children were enrolled in four neighboring elementary schools in Sweden, from a middle‐class socioeconomic status, and each school was government funded, necessitating use of a compulsory standard Swedish physical education curriculum. Although representing a convenience sample, these aspects of the study are noteworthy because there was less variability at baseline with respect to physical activity. The four schools were also similar in size, which is important given how the treatment was assigned in the current exercise intervention trial. One of the four schools was offered to participate as the intervention school, with the other three serving as controls. Fracture incidence was assessed in all participants. Importantly, a sophisticated surveillance system was employed with all fractures verified radiographically. Fractures during the 6‐year period were registered in radiological archives from the hospital and a computerized database that included all radiographs obtained in southern Sweden. As there was only one emergency hospital in the city, virtually all fractures were captured, a unique system that has been previously shown to miss less than 3% of all sustained
登录
查看更多内容
影响因子：
6.2
作者：
Warden, Stuart J.;Galley, Matthew R.;Hurd, Andrea L.;Richard, Jeffrey S.;George, Lydia A.;Guildenbecher, Elizabeth A.;Barker, Rick G.;Fuchs, Robyn K.
通讯作者：
Fuchs, Robyn K.
影响因子：
4.1
作者：
HEINONEN, A;OJA, P;VUORI, I
通讯作者：
VUORI, I
影响因子：
6.2
作者：
Kirmani, Salman;Christen, David;Khosla, Sundeep
通讯作者：
Khosla, Sundeep
影响因子：
6.2
作者：
Goulding, A;Jones, IE;Williams, SM
通讯作者：
Williams, SM
影响因子：
2.5
作者：
Crabtree, Nicola J.;Arabi, Asma;Gordon, Catherine M.
通讯作者：
Gordon, Catherine M.