Non-Invasive Continuous Optical Monitoring of Cerebral Blood Flow after Traumatic Brain Injury in Mice Using Fiber Camera-Based Speckle Contrast Optical Spectroscopy.
Non-Invasive Continuous Optical Monitoring of Cerebral Blood Flow after Traumatic Brain Injury in Mice Using Fiber Camera-Based Speckle Contrast Optical Spectroscopy.
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DOI：
10.3390/brainsci13101365
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发表时间：
2023-09-25
期刊：
影响因子：
3.3
通讯作者：
Sunar U
中科院分区：
文献类型：
--
作者：
Langri DS;Sunar U
神经重症监护专注于监测脑血流（CBF），以在损伤变得不可逆转之前预防继发性脑损伤。因此，对于连续的神经监测方法存在关键的未满足需求，这些方法要能够连续且无创地对易损皮质内的脑血流进行量化。动物模型和影像生物标志物能够为头部损伤的机制和动力学以及潜在治疗策略提供有价值的见解。为此，我们在小鼠模型中实施了一种光学技术，用于在闭合性头部损伤后连续监测血流变化，该技术基于激光散斑衬比成像和基于光纤相机的方法。我们的结果表明，在闭合性头部损伤后的30分钟内，血流显著减少（约10%，p值<0.05）。此外，低频振荡分析还表明，与对照组相比，创伤组的功率要低得多。总体而言，血流有可能成为创伤早期头部损伤的生物标志物，并且该系统对于连续监测是有用的，具有临床转化的潜力。
Neurocritical care focuses on monitoring cerebral blood flow (CBF) to prevent secondary brain injuries before damage becomes irreversible. Thus, there is a critical unmet need for continuous neuromonitoring methods to quantify CBF within the vulnerable cortex continuously and non-invasively. Animal models and imaging biomarkers can provide valuable insights into the mechanisms and kinetics of head injury, as well as insights for potential treatment strategies. For this purpose, we implemented an optical technique for continuous monitoring of blood flow changes after a closed head injury in a mouse model, which is based on laser speckle contrast imaging and a fiber camera-based approach. Our results indicate a significant decrease (~10%, p-value < 0.05) in blood flow within 30 min of a closed head injury. Furthermore, the low-frequency oscillation analysis also indicated much lower power in the trauma group compared to the control group. Overall, blood flow has the potential to be a biomarker for head injuries in the early phase of a trauma, and the system is useful for continuous monitoring with the potential for clinical translation.
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