Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets.
Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets.
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DOI：
10.1002/jbio.202000366
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发表时间：
2021-04
影响因子：
2.8
通讯作者：
Chen L
中科院分区：
文献类型：
--
作者：
Huang C;Mazdeyasna S;Mohtasebi M;Saatman KE;Cheng Q;Yu G;Chen L
我们采用并测试了一种创新的非接触式散斑对比度扩散相关断层扫描（scDCT）系统，用于利用新生仔猪（与人类新生儿非常相似）进行围产期疾病模型脑血流（CBF）变化的3D成像。在全脑缺血、脑室内出血和窒息期间，通过scDCT和已建立的弥散相关光谱（DCS）同时测量CBF变化;观察到显著相关性。此外，CBF的变化与重要的病理生理变化合理相关。与DCS测量来自局部头皮、颅骨和大脑的混合信号相反，scDCT在头部内的规定深度处生成CBF分布的3D图像，从而能够具体确定局部脑缺血。随着在动物和人类新生儿中的进一步优化和验证，scDCT有可能成为实验室基础神经科学研究和新生儿重症监护室临床应用的无创成像工具。
We adapted and tested an innovative noncontact speckle contrast diffuse correlation tomography (scDCT) system for 3D imaging of cerebral blood flow (CBF) variations in perinatal disease models utilizing neonatal piglets, which closely resemble human neonates. CBF variations were concurrently measured by the scDCT and an established diffuse correlation spectroscopy (DCS) during global ischemia, intraventricular hemorrhage, and asphyxia; significant correlations were observed. Moreover, CBF variations associated reasonably with vital pathophysiological changes. In contrast to DCS measurements of mixed signals from local scalp, skull and brain, scDCT generates 3D images of CBF distributions at prescribed depths within the head, thus enabling specific determination of regional cerebral ischemia. With further optimization and validation in animals and human neonates, scDCT has the potential to be a noninvasive imaging tool for both basic neuroscience research in laboratories and clinical applications in neonatal intensive care units.
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影响因子：
5.7
作者：
Eggebrecht, Adam T.;White, Brian R.;Ferradal, Silvina L.;Chen, Chunxiao;Zhan, Yuxuan;Snyder, Abraham Z.;Dehghani, Hamid;Culver, Joseph P.
通讯作者：
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作者：
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通讯作者：
Nuyt, Anne Monique
DOI：
10.1097/00004647-200405000-00005
发表时间：
2004-05-01
影响因子：
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通讯作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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