Two related but differentially expressed potential membrane proteins encoded by the EcoRI Dhet region of Epstein-Barr virus B95-8
Two related but differentially expressed potential membrane proteins encoded by the EcoRI Dhet region of Epstein-Barr virus B95-8
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由 Epstein-Barr 病毒 B95-8 的 EcoRI Dhet 区域编码的两个相关但差异表达的潜在膜蛋白
作者：
G. Hudson;P. Farrell;B. Barrell
绘制了 Epstein-Barr 病毒 B95-8 的 EcoRI Dhet 区域中的 3 个 mRNA。它们的 3' 末端是共端的。包含三个外显子的潜在基因从 ED-L1 启动子转录，预计会导致 42 千道尔顿蛋白质的表达。未剪接的晚期 mRNA 由上述基因第一个内含子内的 ED-L1A 启动子转录产生，预计会导致 28 千道尔顿蛋白质的表达，对应于 42 千道尔顿蛋白质 C 端的三分之二。两种蛋白质都具有疏水性 N 端结构域和高酸性 C 端结构域，并且预计会跨越细胞膜。早期启动子（ED-L2）位于上述基因的3'非翻译区，预计会导致含有C端疏水区的6.5千道尔顿多肽的表达。
Three mRNAs in the EcoRI Dhet region of Epstein-Barr virus B95-8 were mapped. Their 3' ends are coterminal. A latent gene containing three exons is transcribed from the ED-L1 promoter and was predicted to lead to expression of a 42-kilodalton protein. An unspliced late mRNA is produced by transcription from the ED-L1A promoter within the first intron of the above gene and was predicted to lead to expression of a 28-kilodalton protein corresponding to the C-terminal two-thirds of the 42-kilodalton protein. Both proteins would have hydrophobic N-terminal domains and highly acidic C-terminal domains and were predicted to span the cell membrane. An early promoter (ED-L2) is located in the 3' untranslated region of the above genes and was predicted to lead to expression of a 6.5-kilodalton polypeptide containing a C-terminal hydrophobic region.
单克隆抗体识别感染 Epstein-Barr 病毒的人 B 细胞上的膜抗原。
DOI：
10.1073/pnas.79.8.2649
发表时间：
1982
影响因子：
11.1
作者：
Slovin,SF;Frisman,DM;Tsoukas,CD;Royston,I;Baird,SM;Wormsley,SB;Carson,DA;Vaughan,JH
通讯作者：
Vaughan,JH
爱泼斯坦-巴尔病毒的生物学和化学。
DOI：
10.1093/infdis/146.4.506
发表时间：
1982
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Kieff,E;Dambaugh,T;Heller,M;King,W;Cheung,A;vanSanten,V;Hummel,M;Beisel,C;Fennewald,S;Hennessy,K;Heineman,T
通讯作者：
Heineman,T