Depression and Cardiovascular Disease: The Viewpoint of Platelets.
Depression and Cardiovascular Disease: The Viewpoint of Platelets.
复制标题
抑郁症与心血管疾病：血小板的观点。
DOI：
10.3390/ijms21207560
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发表时间：
2020-10-13
影响因子：
5.6
通讯作者：
Barbieri SS
中科院分区：
文献类型：
--
作者：
Amadio P;Zarà M;Sandrini L;Ieraci A;Barbieri SS
抑郁症是心血管疾病（CVD）患者发病和生活质量低下的主要原因，现在被认为是主要不良心血管事件的独立危险因素。越来越多的证据表明，抑郁症不仅影响心脏事件的预后，而且这两种情况之间存在交叉脆弱性。在解释这种相互作用的几种机制中，血小板活化更有吸引力，将血小板视为大脑功能的潜在镜子。本文就抑郁症与心血管并发症的相关机制进行了综述，强调了血小板行为在抑郁症中作为心血管并发症的触发因素的重要作用。特别是，我们将讨论抑郁症与CVD相关分子之间的关系（例如，儿茶酚胺、脂肪因子、脂质、活性氧和趋化因子），强调它们对血小板活化和相关机制的影响。
Depression is a major cause of morbidity and low quality of life among patients with cardiovascular disease (CVD), and it is now considered as an independent risk factor for major adverse cardiovascular events. Increasing evidence indicates not only that depression worsens the prognosis of cardiac events, but also that a cross-vulnerability between the two conditions occurs. Among the several mechanisms proposed to explain this interplay, platelet activation is the more attractive, seeing platelets as potential mirror of the brain function. In this review, we dissected the mechanisms linking depression and CVD highlighting the critical role of platelet behavior during depression as trigger of cardiovascular complication. In particular, we will discuss the relationship between depression and molecules involved in the CVD (e.g., catecholamines, adipokines, lipids, reactive oxygen species, and chemokines), emphasizing their impact on platelet activation and related mechanisms.
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DOI：
10.1111/j.1440-1681.1992.tb00513.x
发表时间：
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影响因子：
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