Dietary antioxidants and prostate cancer: a review.
Dietary antioxidants and prostate cancer: a review.
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DOI：
10.1080/01635581.2013.806672
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Chun OK
中科院分区：
文献类型：
--
作者：
Vance TM;Su J;Fontham ET;Koo SI;Chun OK
前列腺癌是美国男性中最常见的非皮肤癌症。一些研究调查了前列腺癌和抗氧化剂之间的关系；然而，这些研究的结果并不一致。本文提供了一个系统的研究综述前列腺癌和抗氧化剂的摄入从饮食和补充剂。茶和咖啡似乎可以预防晚期前列腺癌。不同形式的维生素E似乎对前列腺癌有不同的影响，α -生育酚可能会增加患前列腺癌的风险，而γ -生育酚可能会降低患前列腺癌的风险。没有强有力的证据表明硒、维生素C或β -胡萝卜素有有益作用，而番茄红素似乎与疾病风险呈负相关。膳食抗氧化剂对前列腺癌的影响仍然不明确和不确定，不同的抗氧化剂对前列腺癌风险的影响是不同的。需要进一步的研究来阐明抗氧化剂与前列腺癌风险之间的关系，并描绘其潜在的机制。
Prostate cancer is the most common non-cutaneous cancer in men in the United States. Several studies have examined the relationship between prostate cancer and antioxidants; however, the results of these studies are inconsistent. This article provides a systematic review of studies on prostate cancer and antioxidant intake from diet and supplements. Tea and coffee appear to offer protection against advanced prostate cancer. Different forms of vitamin E appear to exert different effects on prostate cancer, with alpha-tocopherol potentially increasing and gamma-tocopherol potentially decreasing risk of the disease. There is no strong evidence for a beneficial effect of selenium, vitamin C, or beta-carotene, while lycopene appears to be negatively associated with risk of the disease. The effect of dietary antioxidants on prostate cancer remains undefined and inconclusive, with different antioxidants affecting prostate cancer risk differentially. Further studies are needed to clarify the relationship between antioxidants and prostate cancer risk and to delineate the underlying mechanisms.
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