A molecular perspective on TH2-promoting cytokine receptors in patients with allergic disease.
A molecular perspective on TH2-promoting cytokine receptors in patients with allergic disease.
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DOI：
10.1016/j.jaci.2013.08.006
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发表时间：
2014-04
影响因子：
14.2
通讯作者：
Woodfolk, Judith A.
中科院分区：
文献类型：
--
作者：
Romeo, Martin J.;Agrawal, Rachana;Pomes, Anna;Woodfolk, Judith A.
细胞因子IL-4、IL-13和TSLP通过其启动、维持和增强Th2反应的能力在过敏性疾病中发挥关键作用。这些分子通过1型细胞因子受体介导其作用，1型细胞因子受体结合具有特征结构的细胞因子。受体在广泛的免疫细胞类型上表达，是健康和疾病中复杂的细胞因子网络的组成部分。促进th2的细胞因子结合不同构型的受体。受体亚基可以表面结合或可溶形式存在，也可以单独存在或与其他亚基合作存在。在不同的细胞因子受体复合物之间共享受体亚基增加了复杂的景观。本文从结构-功能的角度介绍了IL-4、IL-13和TSLP受体的特点及其配体。我们详细介绍了受体复合物组装的机制，这些受体的相互关联的性质，以及对过敏性炎症的影响。还讨论了新型和非典型受体调节炎症过程的能力。我们强调当前和新兴的治疗靶向th2促进受体复合物。了解这些受体的分子特征有助于了解不同的疾病表型和靶向治疗引起的不同临床结果。这些考虑可以用来为未来的研究方向和治疗个体患者的创造性策略提供信息。
The cytokines IL-4, IL-13 and TSLP, play a key role in allergic disease by virtue of their ability to initiate, maintain, and augment Th2 responses. These molecules mediate their effects through type 1 cytokine receptors which bind cytokines with a characteristic structure. Receptors are expressed on a broad array of immune cell types, and are integral to complex cytokine networks operating in health and disease. Th2-promoting cytokines bind different configurations of receptors. Receptor subunits may exist in surface bound or soluble form, as well as in isolation or in partnership with other subunits. Sharing of receptor subunits among different cytokine receptor complexes adds to the intricate landscape. This article describes the characteristics of receptors for IL-4, IL-13 and TSLP, and their respective ligands, from a structure-function perspective. We detail the mechanisms of receptor complex assembly, the interrelated nature of these receptors, and impact on allergic inflammation. The ability for novel and atypical types of receptors to modulate inflammatory processes is also discussed. We highlight current and emerging treatments that target Th2-promoting receptor complexes. Understanding molecular features of these receptors provides insight into different disease phenotypes and the variable clinical outcomes arising from targeted therapies. These considerations can be used to inform future directions for research and creative strategies for treating individual patients.
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影响因子：
7.3
作者：
Arima K;Watanabe N;Hanabuchi S;Chang M;Sun SC;Liu YJ
通讯作者：
Liu YJ
DOI：
10.4049/jimmunol.0901028
发表时间：
2009-12-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Chen W;Sivaprasad U;Tabata Y;Gibson AM;Stier MT;Finkelman FD;Hershey GK
通讯作者：
Hershey GK
DOI：
10.1084/jem.169.1.59
发表时间：
1989-01-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Heinzel FP;Sadick MD;Holaday BJ;Coffman RL;Locksley RM
通讯作者：
Locksley RM
影响因子：
14.2
作者：
Campbell-Harding, Gemma;Sawkins, Hannah;Andrews, Allison-Lynn
通讯作者：
Andrews, Allison-Lynn
影响因子：
14.2
作者：
Chen, Weiguo;Tabata, Yasuhiro;Hershey, Gurjit K. Khurana
通讯作者：
Hershey, Gurjit K. Khurana