Coupled changes in hippocampal structure and cognitive ability in later life.
Coupled changes in hippocampal structure and cognitive ability in later life.
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DOI：
10.1002/brb3.838
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发表时间：
2018-03
影响因子：
3.1
通讯作者：
Wardlaw JM
中科院分区：
文献类型：
--
作者：
Anblagan D;Valdés Hernández MC;Ritchie SJ;Aribisala BS;Royle NA;Hamilton IF;Cox SR;Gow AJ;Pattie A;Corley J;Starr JM;Muñoz Maniega S;Bastin ME;Deary IJ;Wardlaw JM
海马体在认知能力中起着重要的作用，而认知能力往往会随着年龄的增长而下降。在一项对社区居民成年人的纵向研究中，我们调查了73岁（N = 655）至76岁（N = 469）之间海马结构和言语记忆、工作记忆和处理速度是否存在耦合变化。海马结构的指标包括海马体积、海马体积占颅内体积的百分比（H_ICV）、各向异性分数（FA）、平均扩散率（MD）和纵向弛豫时间（T1）。从73岁到76岁，海马体积、H_ICV、FA、T1和所有三个认知能力领域的平均水平下降，而MD增加。在基线时，海马体积越大，工作记忆和文字记忆越好，但这些相关性在多重比较中没有一个得以校正。基线时较高的FA、较低的MD和较低的T1与所有三个领域中较好的认知能力相关;只有基线海马MD和T1之间的相关性以及三个认知领域的变化在多重比较中得以校正。73岁时海马MD较高的个体在73岁至76岁之间的所有三种认知能力都出现了更大的下降。然而，在基线时，海马体积、FA和T1测量与认知能力的变化无显著相关性。同样，73岁时的认知能力与73岁至76岁之间海马MRI生物标志物的变化之间没有显着关联。我们的研究结果提供了证据，以更好地了解健康成年人海马体的年龄与其所涉及的认知领域的关系，这表明73岁时海马体MD更好预测未来3年内三个重要认知领域的相对下降。它可能有助于诊断与衰老相关的神经病理学的早期阶段，因为在某些情况下，加速衰退可以预测病理学。
The hippocampus plays an important role in cognitive abilities which often decline with advancing age. In a longitudinal study of community‐dwelling adults, we investigated whether there were coupled changes in hippocampal structure and verbal memory, working memory, and processing speed between the ages of 73 (N = 655) and 76 years (N = 469). Hippocampal structure was indexed by hippocampal volume, hippocampal volume as a percentage of intracranial volume (H_ICV), fractional anisotropy (FA), mean diffusivity (MD), and longitudinal relaxation time (T1). Mean levels of hippocampal volume, H_ICV, FA, T1, and all three cognitive abilities domains decreased, whereas MD increased, from age 73 to 76. At baseline, higher hippocampal volume was associated with better working memory and verbal memory, but none of these correlations survived correction for multiple comparisons. Higher FA, lower MD, and lower T1 at baseline were associated with better cognitive abilities in all three domains; only the correlation between baseline hippocampal MD and T1, and change in the three cognitive domains, survived correction for multiple comparisons. Individuals with higher hippocampal MD at age 73 experienced a greater decline in all three cognitive abilities between ages 73 and 76. However, no significant associations with changes in cognitive abilities were found with hippocampal volume, FA, and T1 measures at baseline. Similarly, no significant associations were found between cognitive abilities at age 73 and changes in the hippocampal MRI biomarkers between ages 73 and 76. Our results provide evidence to better understand how the hippocampus ages in healthy adults in relation to the cognitive domains in which it is involved, suggesting that better hippocampal MD at age 73 predicts less relative decline in three important cognitive domains across the next 3 years. It can potentially assist in diagnosing early stages of aging‐related neuropathologies, because in some cases, accelerated decline could predict pathologies.
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影响因子：
4.1
作者：
Deary IJ;Gow AJ;Taylor MD;Corley J;Brett C;Wilson V;Campbell H;Whalley LJ;Visscher PM;Porteous DJ;Starr JM
通讯作者：
Starr JM
影响因子：
5.7
作者：
Deary, IJ;Simonotto, E;Wardlaw, JM
通讯作者：
Wardlaw, JM
影响因子：
2.5
作者：
Armitage, Paul A.;Farrall, Andrew J.;Wardlaw, Joanna M.
通讯作者：
Wardlaw, Joanna M.
影响因子：
9.9
作者：
Carlesimo, Giovanni A.;Cherubini, Andrea;Spalletta, Gianfranco
通讯作者：
Spalletta, Gianfranco
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y