The missing mechanistic link: Improving behavioral treatment efficacy for pediatric chronic pain.

The missing mechanistic link: Improving behavioral treatment efficacy for pediatric chronic pain.
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缺失的机械链接:提高小儿慢性疼痛的行为治疗功效。

DOI:
10.3389/fpain.2022.1022699
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发表时间:
2022
期刊:
Frontiers in pain research (Lausanne, Switzerland)
影响因子:
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其他
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儿科慢性疼痛是一个重要的全球性问题,生物心理社会因素导致病情的复杂性。研究探索了儿童慢性疼痛的行为治疗,但这些治疗对改善功能和心理结果的疗效参差不齐。此外,文献缺乏对儿科慢性疼痛治疗反应的生物行为机制的理解。在这篇小型综述中,我们重点介绍了神经影像学如何用于识别不同条件下的生物行为机制,以及如何在机械临床试验中使用这种方式来识别儿科慢性疼痛治疗反应的标志物。我们建议,机械临床试验,利用神经影像学,有必要研究如何优化行为治疗的疗效,为儿童慢性疼痛患者的疼痛类型和年龄。
Pediatric chronic pain is a significant global issue, with biopsychosocial factors contributing to the complexity of the condition. Studies have explored behavioral treatments for pediatric chronic pain, but these treatments have mixed efficacy for improving functional and psychological outcomes. Furthermore, the literature lacks an understanding of the biobehavioral mechanisms contributing to pediatric chronic pain treatment response. In this mini review, we focus on how neuroimaging has been used to identify biobehavioral mechanisms of different conditions and how this modality can be used in mechanistic clinical trials to identify markers of treatment response for pediatric chronic pain. We propose that mechanistic clinical trials, utilizing neuroimaging, are warranted to investigate how to optimize the efficacy of behavioral treatments for pediatric chronic pain patients across pain types and ages.
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