Dysfunctional reward processing in male alcoholics: an ERP study during a gambling task.
Dysfunctional reward processing in male alcoholics: an ERP study during a gambling task.
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DOI：
10.1016/j.jpsychires.2009.11.019
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发表时间：
2010-07
影响因子：
4.8
通讯作者：
Porjesz B
中科院分区：
文献类型：
--
作者：
Kamarajan C;Rangaswamy M;Tang Y;Chorlian DB;Pandey AK;Roopesh BN;Manz N;Saunders R;Stimus AT;Porjesz B
一个功能失调的神经奖励系统已被证明与酗酒有关。本研究旨在通过事件相关电位（ERPs）以及冲动和冒险行为的测量来研究男性酗酒者的奖励加工。结果相关的消极（ORN/N2）和积极（ORP/P3）来自一个单一的结果赌博任务使用混合模型程序进行了分析。使用标准化低分辨率电磁断层扫描（sLORETA）比较各组和结局的电流密度。还比较了各组的行为评分。并对ERP各因子与行为因子、冲动因子的相关性进行了分析。酒精中毒者在ORP分量的所有结果条件下显示出比对照组显著更低的振幅，并且在ORN分量的损失条件下显示出降低的振幅。在条件内，增益产生比损失条件更高的振幅。从地形上看，两组在Loss条件下均具有前部焦点，在Gain条件下均具有后部最大值，尤其是ORN组件。酗酒者扣带回的ORP电流密度降低，感觉和运动区的负ORN电流密度降低。酗酒者比对照组有更高水平的冲动和冒险特征。结果/奖励处理缺陷和增加冲动性和冒险行为在酗酒者中观察到的可能至少部分是由于奖励缺陷和/或功能失调的奖励电路在大脑中，这表明酗酒可以被认为是奖励缺陷综合征（RDS）集群的一部分。
A dysfunctional neural reward system has been shown to be associated with alcoholism. The current study aims to examine reward processing in male alcoholics by using event related potentials (ERPs) as well as behavioral measures of impulsivity and risk-taking. Outcome related negativity (ORN/N2) and positivity (ORP/P3) derived from a single outcome gambling task were analyzed using a mixed model procedure. Current density was compared across groups and outcomes using standardized low resolution electromagnetic tomography (sLORETA). Behavioral scores were also compared across groups. Correlations of ERP factors with behavioral and impulsivity factors were also analyzed. Alcoholics showed significantly lower amplitude than controls during all outcome conditions for the ORP component and decreased amplitude during the loss conditions for the ORN component. Within conditions, Gain produced higher amplitudes than Loss conditions. Topographically, both groups had an anterior focus during Loss conditions and posterior maxima during Gain conditions, especially for the ORN component. Decreased ORP current density at cingulate gyrus and less negative ORN current density at sensory and motor areas characterized the alcoholics. Alcoholics had higher levels of impulsivity and risk-taking features than controls. Deficient outcome/reward processing and increased impulsivity and risk-taking observed in alcoholics may be at least partly due to reward deficiency and/or dysfunctional reward circuitry in the brain, suggesting that alcoholism can be considered as part of the cluster of the reward deficiency syndrome (RDS).
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影响因子：
17.3
作者：
Blum, K;Sheridan, PJ;Comings, DE
通讯作者：
Comings, DE
DOI：
10.1053/scnp.2001.22927
发表时间：
2001-07-01
期刊：
Seminars in clinical neuropsychiatry
影响因子：
--
作者：
Bechara, A
通讯作者：
Bechara, A
DOI：
10.1111/j.1530-0277.2006.00202.x
发表时间：
2006-10-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Dom, Geert;De Wilde, Bieke;Sabbe, Bernard
通讯作者：
Sabbe, Bernard
影响因子：
10.6
作者：
Cavedini, P;Riboldi, G;Bellodi, L
通讯作者：
Bellodi, L
影响因子：
--
作者：
Dick, Danielle M.;Aliev, Fazil;Goate, Alison
通讯作者：
Goate, Alison