Early-onset depressive disorders predict the use of addictive substances in adolescence: a prospective study of adolescent Finnish twins.
Early-onset depressive disorders predict the use of addictive substances in adolescence: a prospective study of adolescent Finnish twins.
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DOI：
10.1111/j.1360-0443.2008.02363.x
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发表时间：
2008-12
期刊：
影响因子：
--
通讯作者：
Kaprio J
中科院分区：
文献类型：
--
作者：
Sihvola E;Rose RJ;Dick DM;Pulkkinen L;Marttunen M;Kaprio J
探讨早发性抑郁障碍与后来使用成瘾物质之间的发展关系。1545例青少年双胞胎的样本来自一项对芬兰青少年双胞胎的前瞻性纵向研究，基线评估为14岁，随访为17.5岁。在基线时，DSM-IV诊断进行了评估与专业管理的青少年版本的酒精中毒遗传学半结构化评估（C-SSAGA-A）。在随访时，通过自我报告问卷评估物质使用结果。早发性抑郁障碍与每日吸烟的关系（比值比2.29，95%CI 1.49-3.50，p<0.001），无烟烟草使用（OR = 2.00，95%CI 1.32-3.04，p=.001），频繁使用非法药物（OR = 4.71，95%CI 1.95-11.37，p= 0.001）、频繁饮酒（OR = 2.02，95%CI 1.04-3.92，p= 0.037）和三年后复发性中毒（OR = 1.83，95%CI 1.18-2.85，p= 0.007）。在校正合并症和排除基线使用者后，比值比仍然显著。在对抑郁症不一致的双胞胎进行的家庭内分析（控制共享遗传和家庭背景因素的分析）中，14岁时的早发性抑郁症显著预测了17.5岁时经常使用无烟烟草和酒精。我们的研究结果表明，早发性抑郁症和成瘾物质使用之间存在重要的预测关联，这些关联似乎独立于共同的家庭影响。
To explore the developmental relationships between early-onset depressive disorders and later use of addictive substances. A sample of 1545 adolescent twins was drawn from a prospective, longitudinal study of Finnish adolescent twins with baseline assessments at age 14 and follow-up at age 17.5. At baseline, DSM-IV diagnoses were assessed with a professionally administered adolescent version of Semi-Structured Assessment for Genetics of Alcoholism (C-SSAGA-A). At follow-up, substance use outcomes were assessed via self-reported questionnaire. Early-onset depressive disorders predicted daily smoking (odds ratio 2.29, 95%CI 1.49-3.50, p<.001), smokeless tobacco use (OR = 2.00, 95%CI 1.32-3.04, p=.001), frequent illicit drug use (OR = 4.71, 95%CI 1.95-11.37, p=.001), frequent alcohol use (OR = 2.02, 95%CI 1.04-3.92, p=.037) and recurrent intoxication (OR = 1.83, 95%CI 1.18-2.85, p=.007) three years later. Odds ratios remained significant after adjustment for comorbidity and exclusion of baseline users. In within-family analysis of depression-discordant co-twins (analyses that control for shared genetic and familial background factors), early-onset depressive disorders at age 14 significantly predicted frequent use of smokeless tobacco and alcohol at age 17.5. Our results suggest important predictive associations between early—onset depressive disorders and addictive substance use, and these associations appear to be independent of shared familial influences.
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影响因子：
3.8
作者：
Coogan, PF;Geller, A;Adams, M
通讯作者：
Adams, M
DOI：
10.1097/chi.0b013e3180cc255f
发表时间：
2007-09-01
影响因子：
13.3
作者：
Rice, Frances;Lifford, Kate J.;Thapar, Anita
通讯作者：
Thapar, Anita
影响因子：
10.6
作者：
Hudziak, JJ;Althoff, RR;Boomsma, DI
通讯作者：
Boomsma, DI
影响因子：
4.4
作者：
Kumpulainen, K;Roine, S
通讯作者：
Roine, S
影响因子：
6
作者：
Munafo, Marcus R.;Hitsman, Brian;Niaura, Raymond
通讯作者：
Niaura, Raymond