Effects of Inflammation on Multiscale Biomechanical Properties of Cartilaginous Cells and Tissues.
Effects of Inflammation on Multiscale Biomechanical Properties of Cartilaginous Cells and Tissues.
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DOI：
10.1021/acsbiomaterials.6b00671
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发表时间：
2017-11-13
影响因子：
5.8
通讯作者：
Chahine NO
中科院分区：
文献类型：
--
作者：
Nguyen QT;Jacobsen TD;Chahine NO
软骨组织中的细胞是机械敏感的，因此需要机械负荷来调节组织的动态平衡和新陈代谢。机械负荷在细胞分化、增殖、生物合成和动态平衡中起着至关重要的作用。炎症是发生在多个过程中的重要事件，如衰老、损伤和疾病。炎症对细胞和组织的生物过程和机械功能有重要影响。这些效应高度依赖于细胞/组织的类型、时间和大小。在这篇综述中，我们总结了炎症对软骨组织亚细胞、细胞和组织水平的多尺度力学特性的影响，包括机械转导和机械敏感性的变化。重点是关节软骨和椎间盘，在退行性疾病中，如骨关节炎、关节痛和背痛时，它们会受到炎性侮辱的影响。为了概述体内发生的致炎级联反应，不同的炎症刺激已被用于体外和原位研究，包括肿瘤坏死因子(TNF)、各种白介素类(IL)和脂多糖(LPS)。因此，这篇综述将集中于这些刺激的作用，因为它们是软骨组织中研究最好的促炎细胞因子。了解炎症和细胞/组织生物力学领域的现状，可能会确定具有多尺度生物力学考虑的新型和转化性治疗的未来方向。
Cells within cartilaginous tissues are mechanosensitive and thus require mechanical loading for regulation of tissue homeostasis and metabolism. Mechanical loading plays critical roles in cell differentiation, proliferation, biosynthesis, and homeostasis. Inflammation is an important event occurring during multiple processes, such as aging, injury, and disease. Inflammation has significant effects on biological processes as well as mechanical function of cells and tissues. These effects are highly dependent on cell/tissue type, timing, and magnitude. In this review, we summarize key findings pertaining to effects of inflammation on multiscale mechanical properties at subcellular, cellular, and tissue level in cartilaginous tissues, including alterations in mechanotransduction and mechanosensitivity. The emphasis is on articular cartilage and the intervertebral disc, which are impacted by inflammatory insults during degenerative conditions such as osteoarthritis, joint pain, and back pain. To recapitulate the pro-inflammatory cascades that occur in vivo, different inflammatory stimuli have been used for in vitro and in situ studies, including tumor necrosis factor (TNF), various interleukins (IL), and lipopolysaccharide (LPS). Therefore, this review will focus on the effects of these stimuli because they are the best studied pro-inflammatory cytokines in cartilaginous tissues. Understanding the current state of the field of inflammation and cell/tissue biomechanics may potentially identify future directions for novel and translational therapeutics with multiscale biomechanical considerations.
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影响因子：
7
作者：
Bajpayee AG;Quadir MA;Hammond PT;Grodzinsky AJ
通讯作者：
Grodzinsky AJ
影响因子：
2.4
作者：
Alexopoulos, LG;Williams, GM;Guilak, F
通讯作者：
Guilak, F
影响因子：
3.1
作者：
Alkhatib, B.;Rosenzweig, D. H.;Haglund, L.
通讯作者：
Haglund, L.
DOI：
10.1196/annals.1397.069
发表时间：
2007-01-01
期刊：
SIGNAL TRANSDUCTION PATHWAYS, PT D
影响因子：
--
作者：
Bachmeier, Beatrice E.;Nerlich, Andreas G.;Boos, Norbert
通讯作者：
Boos, Norbert
影响因子：
3
作者：
Ahn, SH;Cho, YW;Kim, HS
通讯作者：
Kim, HS