The pathobiology of ozone-induced damage.
The pathobiology of ozone-induced damage.
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臭氧引起的损伤的病理学。
DOI：
--
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
D. Gil
中科院分区：
文献类型：
--
作者：
J. Steinberg;J. Gleeson;D. Gil
臭氧仍然是世界上三种最重要的空气污染物之一，但几乎没有直接记录的证据表明其遗传毒性。对臭氧暴露的病理学及其过程中的分子事件的兴趣源于氧应激引起的DNA损伤，包括羟基自由基，超氧化物，单线态氧和过氧化氢。虽然与臭氧吸入相关的组织损伤发生在传导气道和肺泡，但这些事件背后的细胞和机械过程尚不清楚。臭氧导致多不饱和脂肪酸的氧化分解。臭氧还以剂量依赖性方式（浓度，1-10 ppm）抑制V79中国仓鼠肺成纤维细胞中的DNA复制，这表明臭氧或其反应产物可能直接与DNA相互作用并抑制复制。臭氧还使环状DNA线性化，并诱导臭氧敏感突变体和肺细胞修复其DNA。DNA加合物与衰老、细胞转化、诱变、致癌和细胞死亡有关; DNA加合物是自由基损伤的产物。这些事件在臭氧暴露中都很常见。最后，DNA结合蛋白是基因表达的强有力的正和负调节剂、增强剂或沉默剂。它们的部分作用可能与它们启动DNA转录蛋白的结合序列从而形成复合物的能力有关。臭氧加合物对DNA结合位点的改变可能会影响mRNA的转录，这是由于DNA结合蛋白的结合改变。这种改变的转录已被证明影响参与胶原和基质调节的生长因子。本次审查将讨论臭氧暴露所涉及的一些复杂问题。（250字处删节）
Ozone remains one of the three most important air pollutants worldwide, yet little direct documented evidence of its genotoxicity exists. The interest in the pathology of ozone exposure and the molecular events that underlie its course stems from DNA damage caused by oxygen stress including hydroxyl radicals, superoxide, singlet oxygen, and hydrogen peroxide. Although the tissue damage associated with ozone inhalation occurs at both the conducting airway and the alveolus, the cellular and mechanistic processes underlying these events are less well understood. Ozone leads to the oxidative decomposition of polyunsaturated fatty acids. Ozone also depresses DNA replication in V79 Chinese hamster lung fibroblasts in a dose-dependent fashion (concentration, 1-10 ppm), which indicates that ozone or its reaction products may interact directly with DNA and inhibit replication. Ozone also linearizes circular DNA and induces ozone-sensitive mutant and pneumocytes to repair its DNA. DNA adducts have been implicated in aging, cellular transformation, mutagenesis, carcinogenesis, and cell death; DNA adducts are products of free radical damage. These events are all common in ozone exposure. Finally, DNA-binding proteins are potent positive and negative regulators, enhancers, or silencers of gene expression. Part of their action may be related to their ability to initiate the binding sequence of DNA transcription proteins and thus form complexes. Alteration of DNA-binding sites by ozone adducts may effect mRNA transcription due to altered binding by DNA-binding proteins. This altered transcription has been shown to effect growth factors involved in collagen and matrix regulation. The present review will address some of the complexities involved in ozone exposure.(ABSTRACT TRUNCATED AT 250 WORDS)
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刺激暴露于低水平臭氧的小鼠肺部的聚（ADP-核糖）合成酶活性。
影响因子：
3.9
作者：
Hussain,MZ;Mustafa,MG;Ghani,QP;Bhatnagar,RS
通讯作者：
Bhatnagar,RS
佛波酯刺激的巨噬细胞在 NIH-3T3 细胞中诱导 5,6-环饱和胸腺嘧啶碱基：活性氧中间体的作用。
影响因子：
11.2
作者：
Lewis,JG;Adams,DO
通讯作者：
Adams,DO
DOI：
10.1080/15287398409530493
发表时间：
1984
期刊：
Journal of toxicology and environmental health
影响因子：
--
作者：
Daniel B. Menzel
通讯作者：
Daniel B. Menzel
甲氨蝶呤对动物细胞中 dUTP 水平的影响。
DOI：
--
发表时间：
1980
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Goulian,M;Bleile,B;Tseng,BY
通讯作者：
Tseng,BY
DNA 中嘌呤损伤导致酶促尿嘧啶切除的干扰。
DOI：
10.1073/pnas.79.16.4878
发表时间：
1982
影响因子：
11.1
作者：
Duker,NJ;Jensen,DE;Hart,DM;Fishbein,DE
通讯作者：
Fishbein,DE