Effect of antibiotic use for acute bronchiolitis on new-onset asthma in children.
Effect of antibiotic use for acute bronchiolitis on new-onset asthma in children.
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DOI：
10.1038/s41598-018-24348-5
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发表时间：
2018-04-17
影响因子：
4.6
通讯作者：
Hung CH
中科院分区：
文献类型：
--
作者：
Chen IL;Huang HC;Chang YH;Huang HY;Yeh WJ;Wu TY;Suen JL;Yang SN;Hung CH
早期使用抗生素与哮喘有关。我们调查了2005-2010年间台湾儿童早期毛细支气管炎抗生素使用对新发哮喘发展的影响。数据来自2010年国家健康保险研究数据库，疾病使用国际疾病分类(ICD)进行编码。我们将所有患有毛细支气管炎的患者分为哮喘患者和非哮喘患者。哮喘的诊断使用ICD标准，并在一年内两次使用吸入性支气管扩张剂和/或皮质类固醇。我们确定了哮喘的发病年龄、性别、居住地区、特应性和非甾体类抗炎药的使用史、首次使用抗生素的年龄和特定的抗生素，并使用条件Logistic回归分析对这些因素进行了调整。在所有个体中，新发哮喘的风险与大剂量抗生素的使用有关(调整后的优势比[ = ]3.33，95%可信区间[CI] = 2.67-4.15)。在不同的抗生素中，大环内酯类(AOR = 2.87，95%CI = 1.99~4.16)和阿奇霉素(AOR = 3.45，95%CI = 1.62~7.36)对哮喘的影响最大。
Early-life use of antibiotics is associated with asthma. We examined the effect of antibiotic use for early-life bronchiolitis on the development of new-onset asthma in children from Taiwan between 2005 and 2010. Data were from the National Health Insurance Research Database 2010, and diseases were coded using the International Classification of Disease (ICD). We classified the patients, all of whom had bronchiolitis, as having asthma or not having asthma. Asthma was diagnosed using ICD criteria and by use of an inhaled bronchodilator and/or corticosteroid twice in one year. We identified age at asthma onset, sex, residential area, history of atopy and NSAID use, age at first use of antibiotics, and the specific antibiotic, and adjusted for these factors using conditional logistic regression analysis. Among all individuals, there was a relationship between risk of new-onset asthma with use of a high dose of an antibiotic (adjusted odds ratio [aOR] = 3.33, 95% confidence interval [CI] = 2.67–4.15). Among the different antibiotics, macrolides (aOR = 2.87, 95% CI = 1.99–4.16), and azithromycin specifically (aOR = 3.45, 95% CI = 1.62–7.36), had the greatest effect of development of asthma.
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随机试验评估阿奇霉素对血清和上呼吸道IL-8水平的影响，并在患有呼吸道合胞病毒细支气管炎的婴儿中复发。
DOI：
10.1016/j.jaci.2014.10.001
发表时间：
2015-05
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Beigelman A;Isaacson-Schmid M;Sajol G;Baty J;Rodriguez OM;Leege E;Lyons K;Schweiger TL;Zheng J;Schechtman KB;Castro M;Bacharier LB
通讯作者：
Bacharier LB
影响因子：
4.6
作者：
Sykes L;MacIntyre DA;Yap XJ;Teoh TG;Bennett PR
通讯作者：
Bennett PR
影响因子：
5.2
作者：
Versporten, Ann;Bielicki, Julia;Goossens, Herman
通讯作者：
Goossens, Herman
影响因子：
168.9
作者：
Gibson, Peter G.;Yang, Ian A.;Simpson, Jodie L.
通讯作者：
Simpson, Jodie L.
影响因子：
6.1
作者：
Abrahamsson, T. R.;Abelius, M. Sandberg;Jenmalm, M. C.
通讯作者：
Jenmalm, M. C.