The Th1:th2 dichotomy of pregnancy and preterm labour.
The Th1:th2 dichotomy of pregnancy and preterm labour.
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DOI：
10.1155/2012/967629
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发表时间：
2012
影响因子：
4.6
通讯作者：
Bennett PR
中科院分区：
文献类型：
--
作者：
Sykes L;MacIntyre DA;Yap XJ;Teoh TG;Bennett PR
妊娠是一种独特的免疫状态，需要平衡免疫耐受和抑制，以保护胎儿而不损害母亲。长期以来，人们已经确定，从T辅助细胞1细胞因子谱向T辅助细胞2谱的偏倚有助于成功的妊娠维持。报道Th1：Th2平衡异常的大多数出版物集中于早期妊娠丢失和先兆子痫。在过去的几十年里，人们越来越认识到感染和炎症在早产中的作用，并继续寻找新的生物标志物来预测早产。在本文中，我们探讨了一个异常的Th1：Th2配置文件与早产的证据。我们还考虑了其用于筛查早产高危妇女的潜力，以及用于预防早产和相关新生儿不良结局的预防性治疗措施。
Pregnancy is a unique immunological state in which a balance of immune tolerance and suppression is needed to protect the fetus without compromising the mother. It has long been established that a bias from the T helper 1 cytokine profile towards the T helper 2 profile contributes towards successful pregnancy maintenance. The majority of publications that report on aberrant Th1:Th2 balance focus on early pregnancy loss and preeclampsia. Over the last few decades, there has been an increased awareness of the role of infection and inflammation in preterm labour, and the search for new biomarkers to predict preterm labour continues. In this paper, we explore the evidence for an aberrant Th1:Th2 profile associated with preterm labour. We also consider the potential for its use in screening women at high risk of preterm labour and for prophylactic therapeutic measures for the prevention of preterm labour and associated neonatal adverse outcomes.
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