Chronic intranasal administration of Aspergillus fumigatus spores leads to aggravation of airway inflammation and remodelling in asthmatic rats

Chronic intranasal administration of Aspergillus fumigatus spores leads to aggravation of airway inflammation and remodelling in asthmatic rats
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长期鼻内给予烟曲霉孢子导致哮喘大鼠气道炎症和重塑加重

DOI:
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发表时间:
2009
期刊:
Respirology (Carlton South. Print)
影响因子:
--
通讯作者:
Xianqiao Jin
Xianqiao Jin
中科院分区:
--
文献类型:
--
作者:
Fu;Jian;Yi Zhang;Xianqiao Jin

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背景和目的:流行病学证据表明真菌暴露与哮喘恶化之间存在密切联系。 然而,真菌作为哮喘发生和发展的外源性促发剂的作用尚未完全研究。在这项研究中,烟曲霉菌暴露对慢性哮喘大鼠模型气道炎症和重塑的影响进行了研究。
Background and objective:  Epidemiological evidence indicates a close link between exposure to fungi and deterioration of asthma. However, the role of fungi as an exogenous precipitant for initiation and progression of asthma has been incompletely explored. In this study, the effects of Aspergillus fumigatus exposure on airway inflammation and remodelling in a rat model of chronic asthma were investigated.
室外真菌孢子浓度对每日哮喘严重程度的影响。
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